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Biosynthesis Literature Biodegradation Method Biosynthesis Precursor

Biosynthesis Reaction
alpha-Ketoisocaproate >> Hydroxymethylglutaryl-CoA (HMG-CoA) [in mitochondrial matrix]
alpha-ketoisocaproate >> Isovaleryl-CoA
alpha-Ketoisovalerate >> alpha-Ketoisocaproate
dimethylcitraconate >> 2-oxoisocaproate
Hydroxy-4-methylpentanoate >> 4-Methyl-2-oxopentanoate
iso-valeryl-CoA >> 4-Methyl-2-oxopentanoate
Isopropylmalate >> Ketoisocaproate
Ketoleucine >> Acetyl-CoA
Ketovaline >> Ketoleucine
L-leucine + 2-oxoglutarate >> 4-methyl-2-oxopentanoate + glutamate