Uniprot ID	A1IQ68
Uniprot Name	CAS9_NEIMA
Taxonomy ID	122587
Sequence	M A A F K P N P I N Y I L G L D I G I A S V G W A M V E I D E D E N P I C L I D L G V R V F E R A E V P K T G D S L A M A R R L A R S V R R L T R R R A H R L L R A R R L L K R E G V L Q A A D F D E N G L I K S L P N T P W Q L R A A A L D R K L T P L E W S A V L L H L I K H R G Y L S Q R K N E G E T A D K E L G A L L K G V A D N A H A L Q T G D F R T P A E L A L N K F E K E S G H I R N Q R G D Y S H T F S R K D L Q A E L I L L F E K Q K E F G N P H V S G G L K E G I E T L L M T Q R P A L S G D A V Q K M L G H C T F E P A E P K A A K N T Y T A E R F I W L T K L N N L R I L E Q G S E R P L T D T E R A T L M D E P Y R K S K L T Y A Q A R K L L G L E D T A F F K G L R Y G K D N A E A S T L M E M K A Y H A I S R A L E K E G L K D K K S P L N L S P E L Q D E I G T A F S L F K T D E D I T G R L K D R I Q P E I L E A L L K H I S F D K F V Q I S L K A L R R I V P L M E Q G K R Y D E A C A E I Y G D H Y G K K N T E E K I Y L P P I P A D E I R N P V V L R A L S Q A R K V I N G V V R R Y G S P A R I H I E T A R E V G K S F K D R K E I E K R Q E E N R K D R E K A A A K F R E Y F P N F V G E P K S K D I L K L R L Y E Q Q H G K C L Y S G K E I N L G R L N E K G Y V E I D H A L P F S R T W D D S F N N K V L V L G S E N Q N K G N Q T P Y E Y F N G K D N S R E W Q E F K A R V E T S R F P R S K K Q R I L L Q K F D E D G F K E R N L N D T R Y V N R F L C Q F V A D R M R L T G K G K K R V F A S N G Q I T N L L R G F W G L R K V R A E N D R H H A L D A V V V A C S T V A M Q Q K I T R F V R Y K E M N A F D G K T I D K E T G E V L H Q K T H F P Q P W E F F A Q E V M I R V F G K P D G K P E F E E A D T P E K L R T L L A E K L S S R P E A V H E Y V T P L F V S R A P N R K M S G Q G H M E T V K S A K R L D E G V S V L R V P L T Q L K L K D L E K M V N R E R E P K L Y E A L K A R L E A H K D D P A K A F A E P F Y K Y D K A G N R T Q Q V K A V R V E Q V Q K T G V W V R N H N G I A D N A T M V R V D V F E K G D K Y Y L V P I Y S W Q V A K G I L P D R A V V Q G K D E E D W Q L I D D S F N F K F S L H P N D L V E V I T K K A R M F G Y F A S C H R G T G N I N I R I H D L D H K I G K N G I L E G I G V K T A L S F Q K Y Q I D E L G K E I R P C R L K K R P P V R
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_01480};
Active site	ACT_SITE 16 16 For RuvC-like nuclease domain. {ECO:0000255|HAMAP-Rule:MF_01480}.; ACT_SITE 588 588 Proton acceptor for HNH nuclease domain. {ECO:0000255|HAMAP-Rule:MF_01480}.
Pfam	PF13395 PF18541
InterPro	IPR028629 IPR033114 IPR003615 IPR036397 IPR041383