Uniprot ID	O09053
Uniprot Name	WRN_MOUSE
Taxonomy ID	10090
Sequence	M E T T S L Q R K F P E W M S M Q S Q R C A T E E K A C V Q K S V L E D N L P F L E F P G S I V Y S Y E A S D C S F L S E D I S M R L S D G D V V G F D M E W P P I Y K P G K R S R V A V I Q L C V S E S K C Y L F H I S S M S V F P Q G L K M L L E N K S I K K A G V G I E G D Q W K L L R D F D V K L E S F V E L T D V A N E K L K C A E T W S L N G L V K H V L G K Q L L K D K S I R C S N W S N F P L T E D Q K L Y A A T D A Y A G L I I Y Q K L G N L G D T A Q V F A L N K A E E N L P L E M K K Q L N S I S E E M R D L A N R F P V T C R N L E T L Q R V P V I L K S I S E N L C S L R K V I C G P T N T E T R L K P G S S F N L L S S E D S A A A G E K E K Q I G K H S T F A K I K E E P W D P E L D S L V K Q E E V D V F R N Q V K Q E K G E S E N E I E D N L L R E D M E R T C V I P S I S E N E L Q D L E Q Q A K E E K Y N D V S H Q L S E H L S P N D D E N D S S Y I I E S D E D L E M E M L K S L E N L N S D V V E P T H S T W L E M G T N G R L P P E E E D G H G N E A I K E E Q E E E D H L L P E P N A K Q I N C L K T Y F G H S S F K P V Q W K V I H S V L E E R R D N V V V M A T G Y G K S L C F Q Y P P V Y T G K I G I V I S P L I S L M E D Q V L Q L E L S N V P A C L L G S A Q S K N I L G D V K L G K Y R V I Y I T P E F C S G N L D L L Q Q L D S S I G I T L I A V D E A H C I S E W G H D F R S S F R M L G S L K T A L P L V P V I A L S A T A S S S I R E D I I S C L N L K D P Q I T C T G F D R P N L Y L E V G R K T G N I L Q D L K P F L V R K A S S A W E F E G P T I I Y C P S R K M T E Q V T A E L G K L N L A C R T Y H A G M K I S E R K D V H H R F L R D E I Q C V V A T V A F G M G I N K A D I R K V I H Y G A P K E M E S Y Y Q E I G R A G R D G L Q S S C H L L W A P A D F N T S R N L L I E I H D E K F R L Y K L K M M V K M E K Y L H S S Q C R R R I I L S H F E D K C L Q K A S L D I M G T E K C C D N C R P R L N H C L T A N N S E D A S Q D F G P Q A F Q L L S A V D I L Q E K F G I G I P I L F L R G S N S Q R L P D K Y R G H R L F G A G K E Q A E S W W K T L S H H L I A E G F L V E V P K E N K Y I K T C S L T K K G R K W L G E A S S Q S P P S L L L Q A N E E M F P R K V L L P S S N P V S P E T T Q H S S N Q N P A G L T T K Q S N L E R T H S Y K V P E K V S S G T N I P K K S A V M P S P G T S S S P L E P A I S A Q E L D A R T G L Y A R L V E A R Q K H A N K M D V P P A I L A T N K V L L D M A K M R P T T V E N M K Q I D G V S E G K A A L L A P L L E V I K H F C Q V T S V Q T D L L S S A K P H K E Q E K S Q E M E K K D C S L P Q S V A V T Y T L F Q E K K M P L H S I A E N R L L P L T A A G M H L A Q A V K A G Y P L D M E R A G L T P E T W K I I M D V I R N P P I N S D M Y K V K L I R M L V P E N L D T Y L I H M A I E I L Q S G S D S R T Q P P C D S S R K R R F P S S A E S C E S C K E S K E A V T E T K A S S S E S K R K L P E W F A K G N V P S A D T G S S S S M A K T K K K G L F S
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:17229737}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:17229737}; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:17229737}; Note=Binds 2 magnesium ions per subunit. Has high activity with manganese and zinc ions (in vitro). {ECO:0000269|PubMed:17229737};
Active site	No current data
Pfam	PF00270 PF01612 PF00271 PF00570 PF14493 PF16124 PF09382
InterPro	IPR002562 IPR011545 IPR004589 IPR014001 IPR001650 IPR029491 IPR010997 IPR002121 IPR027417 IPR032284 IPR012337 IPR036397 IPR018982 IPR036388 IPR036390