Uniprot ID	O16140
Uniprot Name	TOP2_BOMMO
Taxonomy ID	7091
Sequence	M A D I K S M F N K M S S P K Q N G T G E P A P A K G Q K G A I E K I Y Q K K S Q L E H I L L R P D T Y I G S V E R A T E T M W V Y D K V K E C M M Q K E L T S V P D C S F P G L Y K I Y D E I L V N A A D N K Q R D P K M D V I K I D I N Q E T N T I S V Y N N G S G I P V V M H K D E K M Y V P T M I F G H L L T S S N Y N D E E E K V T G G R N G Y G A K L C N I F S T K F T V E T A S K Q Y K K H F K Q T W G S N M T K A S E P K I K D S G K D D D F T K I V F S P D L A K F K M E K L E D D I V L L M S R R A Y D V A A S S Q G V K V Y L N G E R L K I N K F K D Y V D L Y I K G K D D E N G Q P L K V V Y E K V S D R W E V A L T I S D M G F Q Q V S F V N S I A T T K G G K H V D T V A D S V V K N V L E V L K K K N K G G V N I K P Y Q V K T H M W L F V N C L I V N P T F D S Q T K E N M T L Q A K S F G S K C N L S E K F I T A V T K C G L V E S V L T W A K F K A Q D Q L V K A S G K K Q S K L K G I P K L E D A N D A G T K N A H L C T L I L T E G D S A K T L A V S G L S V V G R D H Y G V F P L E G K P L N V R D A S H K Q V L E N V E I N N L I K I L G L Q Y K K K Y N S V D D L K T L R Y G K V M I M A D Q D Q D G S H I K G L I I N F I H H N W P E L L K L P F L E E F I T P I V K A T K K D K E I S F Y S L P E F E E W K K E T E N H H T Y N I K Y Y K G L G T S T S K E A K E Y F Q N M D R H R I R F K Y S G P T D D H H I E L A F S K K G A D Q R K E W L T N H M D E V K R R K E I G L S E R Y L Y T K E T K T V T Y S D F V N L E L V L F S N G D N V R S I P S M I D G L K P G Q R K V I F T C I K R N D K R E V K V A Q L A G S V A E H S A Y H H G E Q S L A M T I V N L A Q N Y V G S N N I N L L E P R G Q F G T R L S G G K D S A S P R Y I F T L M S P L T R L I F H P H D D P L L V H E F E D N Q K I E P V Y Y L P I I P M V L V N G V E G I G T G W S T K I P N Y N P R D I A E N L R R L L D G E K P K V M H P W Y K N F K G N V E G F G D K Y V I S G E A A I L P G D K I E I T E L P V G T W T H N Y K E N V L E P M L G T D K V K P L I S E Y R E Y N T D T T V R F V V S L L P G K L S E I E A E G I H K V F K L Q T T I S M T C M N A F D Y N C C L E K Y D K V E E I L R E F Y D L R V K Y Y V R R K D Y L E G Q L Q A E A D K L S N Q A R F I L K K C D K G L V I E N K K R K A M V E E L I K R G Y A P D P I A D W K K R A S K I Q G L T A L E D D D A Q E S E E E E P E P D P K G K P V D P D K A F Q Q L K E V K K F N Y L L G M S M W M L T K E K K D E L L K Q R D Q K L T E L T T L K N K T A P M L W R E D L D A F L I K L D E V E D K E R R E E L N V N K K T S K A M A G K K N R K S M F D I I P S E N G R R V E P K I S D D L I K R I Q A A E K A K T R K E I K K E Y D P D D P T G I S P S S G E K K P K A R V K K E K P E K A E K P D K V D K A E K T D G L K Q T K L T F K K E P K K K K M T F S G S S S G E M S A S D A E V E V L V P R E R T N A R R A A T R V Q K Y K D G S D D S G S D S E P E L L D N K I D S D H E A P Q T L S I S D E D D D F N I K K N P A K K P A E M D S D C L F D S L I E D A K K D E P Q K T L T K S K S E S I L I R R L N I E R Q R R C D T S V P P K E K A A P K R K L M N V D K D E K K T K K R P A R V M L D Q D S D D E D S I F D S K K G K K K T A A N P K K K A K K K V E S D S E S D F N I S D S S L S D
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 813 813 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250|UniProtKB:P06786}.
Pfam	PF00204 PF00521 PF02518 PF01751 PF16898
InterPro	IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013757 IPR013759 IPR013506 IPR018522 IPR031660 IPR006171 IPR034157