Uniprot ID	O23346
Uniprot Name	HIS5B_ARATH
Taxonomy ID	3702
Sequence	M E L L S S S P A Q L L R P N L S S R A L L P P R T S I A S S H P P P P R F L V M N S Q S Q H R P S I S C A S P P P G D N G F P A I T T A S P I E S A R I G E V K R E T K E T N V S V K I N L D G H G V S D S S T G I P F L D H M L D Q L A S H G L F D V H V R A T G D T H I D D H H T N E D V A L A I G T A L L K A L G E R K G I N R F G D F T A P L D E A L I H V S L D L S G R P Y L G Y N L E I P T Q R V G T Y D T Q L V E H F F Q S L V N T S G M T L H I R Q L A G K N S H H I I E A T F K A F A R A L R Q A T E S D P R R G G T I P S S K G V L S R S
Cofactor	COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:26095028, ECO:0000269|PubMed:27717128}; Note=Binds 2 manganese ions per subunit (PubMed:26095028, PubMed:27717128). Substrate binding triggers a switch in the coordination state of the Mn(2+) active site between six- and five-coordinate species; this switch is critical to prime the active site for catalysis, by facilitating the formation of a high-energy imidazolate intermediate (PubMed:26095028). {ECO:0000269|PubMed:26095028, ECO:0000269|PubMed:27717128};
Active site	No current data
Pfam	PF00475
InterPro	IPR038494 IPR000807 IPR020565 IPR020568