Uniprot ID	O27661
Uniprot Name	TOP1_METTH
Taxonomy ID	187420
Sequence	M R S L S G K M H E V I I C E K P K S S E K I A G A L F P D A M K K K H G K V S Y W E H V E G D K R V T I V S A V G H L Y S L R P R Q S N E E H F F D L E W A P I H E I D K K K G Y V K D Y L N V I R K F A A G A D R Y I H A C D Y D I E G T L I G F N A L K Y G C G E E A L R K T S R M K F S T L T R E E I Q R A Y K N P I E V D Y G Q V D S G A A R H I L D F I F G V N I S R S L M K S V K A A T N R F I K L S A G R V Q T P T L A I L V E R E K E I R D F K P V P Y W I I R A E L G E G I I A E S K R G K I F K R E L V D S I L E K C Q G S D A E V K D V R V R D T I R K P P V P F D L G T L Q S E A Y R V F G F S P K K T Q T I A Q N L Y T E G Y T S Y P R T S S Q K L P E S I G Y E K I L K N L A K N P R F G V H I E R L R G P L K P H E G K K E D D A H P A I H P T G L L P S E L S K D E K K V Y D L I V H R F I S V F G E D A I L Q T M K V E L E I G E E E F S F S R K R V S K A G W M E S Y P Y T K M E D E E F P E I S G G D S L A V R S V S A D E R E T K P P A R Y N E A S L I R E L E R R G L G T K S T R A D I I A K L Y D R K Y I E G K K I R V S P L G E N I I D T L T R Y C E K I I S E E L T R Q F E R E L E D I M R G K I S K D R V I D E A I T E V R S I L S D I E E N L R D I G K E L Y R A Y Q D S R V V G E C P A C G G K L V I K Y S P R N R S T F V G C S S Y P D C R T V Y S L P R G A S V L K S L C E K C G L P M I S Y G R P R Q R A C L D P K C G K K K S E V E E V V G K C P E C G S D L I K R S G R Y G E F V G C K G F P K C R F T C S V D E V P E G
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_00952}; Note=Binds two Mg(2+) per subunit. {ECO:0000255|HAMAP-Rule:MF_00952};
Active site	ACT_SITE 320 320 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000255|HAMAP-Rule:MF_00952}.
Pfam	PF01131 PF01751 PF01396
InterPro	IPR000380 IPR003601 IPR023406 IPR013497 IPR013824 IPR013825 IPR013826 IPR023405 IPR003602 IPR013498 IPR005739 IPR028612 IPR006171 IPR034144