Uniprot ID	O42130
Uniprot Name	TOP2A_CHICK
Taxonomy ID	9031
Sequence	M E L L D S P A P L R P L H D N P R L P K A D G A Q K R L S V E R I Y Q K K T Q L E H I L L R P D T Y I G S V E T V T Q Q M W V F D E D V G L N C R D V T F V P G L Y K I F D E I L V N A A D N K Q R D K S M S C I K V T I D P E N N T I S V W N N G K G I P V V E H K V E K V Y V P A L I F G Q L L T S S N Y D D D E K K V T G G R N G Y G A K L C N I F S T K F T V E T A C R E Y K K L F K Q T W T D N M G K A G E M T L K H F D G E D Y T C V T F Q P D L S K F K M T I L D K D I V A L M S R R A Y D I A G S T K D V K V F L N G K R L P V K G F R S Y V D L Y L K D K V D E T G N A L K V I H E E V N S R W E V C L T L S E K G F Q Q V S F V N S I A T T K G G R H V D Y V A D Q I V T K L I D V V K K K N K N G V G V K P F Q V K N H M W I F V N S L I E N P T F D S Q T K E N M T L Q A K S F G S T C K L S E K F I K G A V G C G I V E S I L N W V K F K A Q T Q L N K K C S A V K H T K I K G V P K L D D A N D A G S K N S I D C T L I L T E G D S A K T L A V S G L G V V G R D K Y G V F P L R G K M L N V R E A S H K Q I M E N A E I N N I I K I V G L Q Y K K N Y E D R E S L K S L R Y G K I M I M T D Q D Q D G S H I K G L L I N F I H H N W P S L L R H N F L E E F I T P I I K V S K N K E E I P F Y S I P E F E E W K S S T Q N Y N S W K I K Y Y K G L G T S T S K E A K E Y F A D M A R H R I G F K Y S G P E D D A A I T L A F S K K K V E E R K E W L T N F M E D R R Q R N V H G L P E D Y L Y G K D T N Y L T Y N D F I N K E L V L F S N S D N E R S I P S L V D G L K P G Q R K V L F T C F K R N D K R E V K G A Q L A G S V A E M S S Y H H G E A S L M M T I I N L A Q N F V G S N N L N L L Q P I G Q F G T R L H G G K D S A S P R Y I F T M L S P L A R L L F P P V D D N V L R F L Y D D N Q R V E P E W Y M P I I P M V L I N G A E G I G T G W S C K I P N F D I R E T V N N I R C L L D G K E P L P M L P S Y K N F K G T I D E L G P N Q Y V I S G E V S I L D S T T I E I T E L P V R T W T Q T Y K E Q V L E P M L N G T E K T P P L I T D Y K E Y H T D T T V K F V V K M S E E K L A E A E A V G L H K V F K L Q T N L T C N S M V L F D H V G F L K K Y E S P Q D I L K E F F E L R L R Y Y G L R K E W L I G M L G A E S A K L N N Q A R F I L E K I D G K I V I E N K P K K E L I Q V L I Q R G Y E S D P V K A W K E L Q N K E E E E G D E S G E E S A A A T G P D F N Y L L N M P L W Y L T K E K K D E L C K Q R D N K D K E L E D L K H K S P S D L W K E D L A A F V E E L D A V E A K Q M Q D E M A G I T G K P L K V K G G K Q G G K Q K V T K A Q L A E V M P S P H G I R V V P R V T A E M K A E A E K R I K K K I K S E K N E S D E K Q E G N S S G D K E P S S L K Q R L A Q K R K A E Q G T K R Q T T L P F K P I K K M K R N P W S D S E S D S E S D D F E V P S K R E R V V R Q A A A K I K P M V N S D S D A D L T S S D E D S E Y Q E N S E G N T D S D T T S K K K P P K A K A V P K E K K G K A P K E K P L P D A V P V R V Q N V A A E S A S Q D P A A P P V S V P R A Q A V P K K P A A A K K G S T A K D N Q P S I M D I L T K K K A A P K A P R R A Q R E E S P P S E A T A A V A K K P G P P R G R K A T K R L T S S S D S D S D F G S R P S K S V A A K K S K R D D D D S Y S I D L T A D S P A A A A P R T R P G R L K K P V Q Y L E S S D E D D M F
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 806 806 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250|UniProtKB:P06786}.
Pfam	PF00204 PF00521 PF08070 PF02518 PF01751 PF16898
InterPro	IPR012542 IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013757 IPR013759 IPR013506 IPR018522 IPR031660 IPR006171 IPR034157