Uniprot ID	O60346
Uniprot Name	PHLP1_HUMAN
Taxonomy ID	9606
Sequence	M E P A A A A T V Q R L P E L G R E D R A S A P A A A A A A A A A A A A A A A A L A A A A G G G R S P E P A L T P A A P S G G N G S G S G A R E E A P G E A P P G P L P G R A G G A G R R R R R G A P Q P I A G G A A P V P G A G G G A N S L L L R R G R L K R N L S A A A A A A S S S S S S S A A A A S H S P G A A G L P A S C S A S A S L C T R S L D R K T L L L K H R Q T L Q L Q P S D R D W V R H Q L Q R G C V H V F D R H M A S T Y L R P V L C T L D T T A G E V A A R L L Q L G H K G G G V V K V L G Q G P G A A A A R E P A E P P P E A G P R L A P P E P R D S E V P P A R S A P G A F G G P P R A P P A D L P L P V G G P G G W S R R A S P A P S D S S P G E P F V G G P V S S P R A P R P V V S D T E S F S L S P S A E S V S D R L D P Y S S G G G S S S S S E E L E A D A A S A P T G V P G Q P R R P G H P A Q P L P L P Q T A S S P Q P Q Q K A P R A I D S P G G A V R E G S C E E K A A A A V A P G G L Q S T P G R S G V T A E K A P P P P P P P T L Y V Q L H G E T T R R L E A E E K P L Q I Q N D Y L F Q L G F G E L W R V Q E E G M D S E I G C L I R F Y A G K P H S T G S S E R I Q L S G M Y N V R K G K M Q L P V N R W T R R Q V I L C G T C L I V S S V K D S L T G K M H V L P L I G G K V E E V K K H Q H C L A F S S S G P Q S Q T Y Y I C F D T F T E Y L R W L R Q V S K V A S Q R I S S V D L S C C S L E H L P A N L F Y S Q D L T H L N L K Q N F L R Q N P S L P A A R G L N E L Q R F T K L K S L N L S N N H L G D F P L A V C S I P T L A E L N V S C N A L R S V P A A V G V M H N L Q T F L L D G N F L Q S L P A E L E N M K Q L S Y L G L S F N E F T D I P E V L E K L T A V D K L C M S G N C V E T L R L Q A L R K M P H I K H V D L R L N V I R K L I A D E V D F L Q H V T Q L D L R D N K L G D L D A M I F N N I E V L H C E R N Q L V T L D I C G Y F L K A L Y A S S N E L V Q L D V Y P V P N Y L S Y M D V S R N R L E N V P E W V C E S R K L E V L D I G H N Q I C E L P A R L F C N S S L R K L L A G H N Q L A R L P E R L E R T S V E V L D V Q H N Q L L E L P P N L L M K A D S L R F L N A S A N K L E S L P P A T L S E E T N S I L Q E L Y L T N N S L T D K C V P L L T G H P H L K I L H M A Y N R L Q S F P A S K M A K L E E L E E I D L S G N K L K A I P T T I M N C R R M H T V I A H S N C I E V F P E V M Q L P E I K C V D L S C N E L S E V T L P E N L P P K L Q E L D L T G N P R L V L D H K T L E L L N N I R C F K I D Q P S T G D A S G A P A V W S H G Y T E A S G V K N K L C V A A L S V N N F C D N R E A L Y G V F D G D R N V E V P Y L L Q C T M S D I L A E E L Q K T K N E E E Y M V N T F I V M Q R K L G T A G Q K L G G A A V L C H I K H D P V D P G G S F T L T S A N V G K C Q T V L C R N G K P L P L S R S Y I M S C E E E L K R I K Q H K A I I T E D G K V N G V T E S T R I L G Y T F L H P S V V P R P H V Q S V L L T P Q D E F F I L G S K G L W D S L S V E E A V E A V R N V P D A L A A A K K L C T L A Q S Y G C H D S I S A V V V Q L S V T E D S F C C C E L S A G G A V P P P S P G I F P P S V N M V I K D R P S D G L G V P S S S S G M A S E I S S E L S T S E M S S E V G S T A S D E P P P G A L S E N S P A Y P S E Q R C M L H P I C L S N S F Q R Q L S S A T F S S A F S D N G L D S D D E E P I E G V F T N G S R V E V E V D I H C S R A K E K E K Q Q H L L Q V P A E A S D E G I V I S A N E D E P G L P R K A D F S A V G T I G R R R A N G S V A P Q E R S H N V I E V A T D A P L R K P G G Y F A A P A Q P D P D D Q F I I P P E L E E E V K E I M K H H Q E Q Q Q Q Q Q P P P P P Q L Q P Q L P R H Y Q L D Q L P D Y Y D T P L
Cofactor	COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 manganese ions per subunit (By similarity). Mn(2+) is inhibitory below pH 8 and activating above pH 8 (PubMed:24892992). {ECO:0000250, ECO:0000269|PubMed:24892992};
Active site	No current data
Pfam	PF00560 PF13516 PF13855 PF00169 PF00481
InterPro	IPR001611 IPR003591 IPR032675 IPR011993 IPR001849 IPR036457 IPR001932