Uniprot ID	O60658
Uniprot Name	PDE8A_HUMAN
Taxonomy ID	9606
Sequence	M G C A P S I H I S E R L V A E D A P S P A A P P L S S G G P R L P Q G Q K T A A L P R T R G A G L L E S E L R D G S G K K V A V A D V Q F G P M R F H Q D Q L Q V L L V F T K E D N Q C N G F C R A C E K A G F K C T V T K E A Q A V L A C F L D K H H D I I I I D H R N P R Q L D A E A L C R S I R S S K L S E N T V I V G V V R R V D R E E L S V M P F I S A G F T R R Y V E N P N I M A C Y N E L L Q L E F G E V R S Q L K L R A C N S V F T A L E N S E D A I E I T S E D R F I Q Y A N P A F E T T M G Y Q S G E L I G K E L G E V P I N E K K A D L L D T I N S C I R I G K E W Q G I Y Y A K K K N G D N I Q Q N V K I I P V I G Q G G K I R H Y V S I I R V C N G N N K A E K I S E C V Q S D T H T D N Q T G K H K D R R K G S L D V K A V A S R A T E V S S Q R R H S S M A R I H S M T I E A P I T K V I N I I N A A Q E S S P M P V T E A L D R V L E I L R T T E L Y S P Q F G A K D D D P H A N D L V G G L M S D G L R R L S G N E Y V L S T K N T Q M V S S N I I T P I S L D D V P P R I A R A M E N E E Y W D F D I F E L E A A T H N R P L I Y L G L K M F A R F G I C E F L H C S E S T L R S W L Q I I E A N Y H S S N P Y H N S T H S A D V L H A T A Y F L S K E R I K E T L D P I D E V A A L I A A T I H D V D H P G R T N S F L C N A G S E L A I L Y N D T A V L E S H H A A L A F Q L T T G D D K C N I F K N M E R N D Y R T L R Q G I I D M V L A T E M T K H F E H V N K F V N S I N K P L A T L E E N G E T D K N Q E V I N T M L R T P E N R T L I K R M L I K C A D V S N P C R P L Q Y C I E W A A R I S E E Y F S Q T D E E K Q Q G L P V V M P V F D R N T C S I P K S Q I S F I D Y F I T D M F D A W D A F V D L P D L M Q H L D N N F K Y W K G L D E M K L R N L R P P P E
Cofactor	COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence={ECO:0000269|PubMed:18983167}; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. {ECO:0000269|PubMed:18983167};
Active site	ACT_SITE 556 556 Proton donor. {ECO:0000250|UniProtKB:O76083}.
Pfam	PF00989 PF00233
InterPro	IPR003607 IPR000014 IPR035965 IPR013767 IPR023088 IPR002073 IPR036971 IPR023174