Uniprot ID	O61078
Uniprot Name	TOP2_LEICH
Taxonomy ID	44271
Sequence	M T Y A S K Y K K L T P I D H V L L R P E M Y V G S I E T Q P T P M Y I F D P E K G R M V W E T M R V N Q G L L K I V D E I L L N A A D N I N N S K G S V R Q T Y I S I H I S D T G E I T V E N D G A G L P I V R S R E H K M Y I P E M V F G H L L T S S N Y N N D S T S T T A G R H G Y G A K L T N I L S T K F S V V C R T D G R E S H M S W T D H M R M A T A P R V N R V D P K E K S V T R V K F M P D Y A H F G F P N A S I S L D M K R V L H K R I M D L A A M F S K I E V R L N N V P F G F R T F T D Y A R L Y S L P G L D G S M P P E P F V Y T S P N G S V A Y V P Q L T Q S P K R I V G V V N G V V T Y N G G T H C N A A M D I L D S C L D S L S K N F K K N G K V V D T N R V Q R H F T V L V F L I Q T Q P K F D S Q S K A R L V S T V T M P R M P K N T L E K Y L E R M P F L E A H V N S M D D Q L A N E L N K E I G A G R R L S S K T L I S A I T K L V D A T S S Q P D G R N I R T L I I T E G D S A K A L A L N S L S S E Q K K Y C G V F P L R G K L L N V R N K N L K R L K T C K G L Q D L F L S L G L E L G K E Y R S P A E L R Y Q R L L V M T D Q D A D G S H I K G L V I N A F E S L W P K L L Q N N P G Y I S L F S T P I V K I K V S G K S K E V I A F H S F R D F H R W Q R A H P S A R Y T A K Y Y K G L G T S T T A E G K E Y F A D M E K N I M Q L T V D A R D H Q L L D S V F D A A E V E W R K E W M T K A N A F Q G E V D I D R S K K T L T I P E F V H K E M V H F A L V G N A R A I P H C V D G L K P S Q R K I L W A M L R R H N S E A S K V A Q L S G Y I S E A S A F H H G E A S L Q E T I V K M A Q N F T G G N N I N L L V P E G Q F G S R Q Q L G N D H A A P R Y I F T K L S R F G R L L F P E E D D P L L D Y M D E E G T F V E P H H Y V P I L P M L L C N G A V G I G F G F A T T I P S F H P L D V S A A V R A M I N G E S A K Q V V R N L V P W A V G F Q G T V R R G P D N E F I A V G K Y T A H P N G R F H I S E I P W M T S I E A F R L H I S S L A S A D V V Q R I A D Y S G A N H I D I D L I V R D G S L T T W A E C E T D L A L A Q R I Y I N G T V F S P T G T L S P I D S D L S P V L Q W H Y D R R L D L Y K R R R T R K I G L M K M D L A R L Q S T R K F V E H F R Q G Q I D F L N A T D D T L H K T C V K L G L V R V D E S F D Y I L K K P I T F F T R T S T E K L Q A D I A K T Q A Q I E E L K R T T P V K M W L T E L D K F D K T F Q E Y E R V L I N S I Q K E Q R S S S I T G G V E L P A L R Q P L L M L G A S A K G A T A Y R V H A C Q Y E K P P P S K R R P G E S V G G A R P S D S A A R T V G K R L V G S R S E F K N K K P M S R K N N V K V S L S T R V A Q X P G A Q L G R L L P H V L M
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 775 775 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250|UniProtKB:P06786}.
Pfam	PF00204 PF00521 PF02518 PF01751 PF16898
InterPro	IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013757 IPR013759 IPR013506 IPR018522 IPR031660 IPR006171