Uniprot ID	O67137
Uniprot Name	TOP4B_AQUAE
Taxonomy ID	224324
Sequence	M K K R Q S Q T P Q E Y T A E A I K A V S G L E H V R L R P A M Y I G D I G E R G L H H L I W E I L D N A V D E A V A G Y A R N I S V T I H R D N S V T V E D D G R G I P V D I H P E T G K P A V E M V F T M L G A G G K F E K K V Y T Y S G G L H G V G A S V V N A L S E W L I V E V Y R D G K I Y R M A F K R G E V V E P L H V V G E T K K R G T K V S F K P D P E I F E T T E I K F D I V E K R V R E L A Y L N P E V K F E L T D E R L G K H L I Y K F D R G I E E L V K Y L N E G K E P L F K D I I R I Q G E K E G V I V D I A F Q Y V K D Y K E R I E S F V N N I K T V E G G T H V T G F R S G L S K A V I R M A Q G L K L A K E L K K S F T G E D V R E G L T A V V A C K V P N P Q F E G Q T K T K L G N Q N V K Q I V E S I T Y D F L T S Y F E K K R D V L K A I V E K A I E A A L A R E A A K K A K E L V R R K S P L E E G V L P G K L A D C S E T D P S K C E I F L V E G D S A G G S A K Q A R D R R Y Q A I L P L R G K I I N V E K A R I D K V L S N D E I K A I V S A L G C G I G E D L D L K K L R Y H K I I L M T D A D V D G S H I R T L L L T F F Y R F M P K L V E E G Y V Y I A E P P L Y R V K K G K K E I Y I K D D K E F E H F L L N E I R E K G R L V D A R E K E F K G E E L V R L L I D L K D Y E D A Y R A L V K S K G E N L V N F L L T H R V R E E D L R N P A R V K E I T H L M E E E L G D Y R V D T K Y N E L E G A Y D I I F Y D D K L G T K T I I D V N F L S S L S Y R E V L E G I H L H L P V Q V F F E N K K V E I N S L G E I Y D K F M D F A R S G M E V Q R Y K G L G E M N P E Q L W E T T M N P K T R R L K K V K I E D A A E A D R I F T I L M G E Q V E P R R E F I E A Y A K E V K H L D V
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_01898}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|HAMAP-Rule:MF_01898}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|HAMAP-Rule:MF_01898}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|HAMAP-Rule:MF_01898};
Active site	No current data
Pfam	PF00204 PF00986 PF02518 PF01751
InterPro	IPR002288 IPR011557 IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR013759 IPR013506 IPR018522 IPR006171 IPR034160