Uniprot ID	O76074
Uniprot Name	PDE5A_HUMAN
Taxonomy ID	9606
Sequence	M E R A G P S F G Q Q R Q Q Q Q P Q Q Q K Q Q Q R D Q D S V E A W L D D H W D F T F S Y F V R K A T R E M V N A W F A E R V H T I P V C K E G I R G H T E S C S C P L Q Q S P R A D N S A P G T P T R K I S A S E F D R P L R P I V V K D S E G T V S F L S D S E K K E Q M P L T P P R F D H D E G D Q C S R L L E L V K D I S S H L D V T A L C H K I F L H I H G L I S A D R Y S L F L V C E D S S N D K F L I S R L F D V A E G S T L E E V S N N C I R L E W N K G I V G H V A A L G E P L N I K D A Y E D P R F N A E V D Q I T G Y K T Q S I L C M P I K N H R E E V V G V A Q A I N K K S G N G G T F T E K D E K D F A A Y L A F C G I V L H N A Q L Y E T S L L E N K R N Q V L L D L A S L I F E E Q Q S L E V I L K K I A A T I I S F M Q V Q K C T I F I V D E D C S D S F S S V F H M E C E E L E K S S D T L T R E H D A N K I N Y M Y A Q Y V K N T M E P L N I P D V S K D K R F P W T T E N T G N V N Q Q C I R S L L C T P I K N G K K N K V I G V C Q L V N K M E E N T G K V K P F N R N D E Q F L E A F V I F C G L G I Q N T Q M Y E A V E R A M A K Q M V T L E V L S Y H A S A A E E E T R E L Q S L A A A V V P S A Q T L K I T D F S F S D F E L S D L E T A L C T I R M F T D L N L V Q N F Q M K H E V L C R W I L S V K K N Y R K N V A Y H N W R H A F N T A Q C M F A A L K A G K I Q N K L T D L E I L A L L I A A L S H D L D H R G V N N S Y I Q R S E H P L A Q L Y C H S I M E H H H F D Q C L M I L N S P G N Q I L S G L S I E E Y K T T L K I I K Q A I L A T D L A L Y I K R R G E F F E L I R K N Q F N L E D P H Q K E L F L A M L M T A C D L S A I T K P W P I Q Q R I A E L V A T E F F D Q G D R E R K E L N I E P T D L M N R E K K N K I P S M Q V G F I D A I C L Q L Y E A L T H V S E D C F P L L D G C R K N R Q K W Q A L A E Q Q E K M L I N G E S G Q A K R N
Cofactor	COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:12955149}; Note=Binds 1 Zn(2+) ion per subunit. Binds 2 divalent metal cations per subunit: site 1 preferentially binds zinc, while site 2 has a preference for magnesium. Tightly binds zinc. {ECO:0000269|PubMed:12955149}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:12955149}; Note=Binds 1 Mg(2+) ions per subunit. Binds 2 divalent metal cations per subunit: site 1 preferentially binds zinc, while site 2 has a preference for magnesium. Binds magnesium less tightly than zinc. {ECO:0000269|PubMed:12955149};
Active site	ACT_SITE 613 613 Proton donor. {ECO:0000250|UniProtKB:O76083}.
Pfam	PF01590 PF00233
InterPro	IPR003018 IPR029016 IPR003607 IPR023088 IPR002073 IPR036971 IPR023174