Uniprot ID	O76083
Uniprot Name	PDE9A_HUMAN
Taxonomy ID	9606
Sequence	M G S G S S S Y R P K A I Y L D I D G R I Q K V I F S K Y C N S S D I M D L F C I A T G L P R N T T I S L L T T D D A M V S I D P T M P A N S E R T P Y K V R P V A I K Q L S A G V E D K R T T S R G Q S A E R P L R D R R V V G L E Q P R R E G A F E S G Q V E P R P R E P Q G C Y Q E G Q R I P P E R E E L I Q S V L A Q V A E Q F S R A F K I N E L K A E V A N H L A V L E K R V E L E G L K V V E I E K C K S D I K K M R E E L A A R S S R T N C P C K Y S F L D N H K K L T P R R D V P T Y P K Y L L S P E T I E A L R K P T F D V W L W E P N E M L S C L E H M Y H D L G L V R D F S I N P V T L R R W L F C V H D N Y R N N P F H N F R H C F C V A Q M M Y S M V W L C S L Q E K F S Q T D I L I L M T A A I C H D L D H P G Y N N T Y Q I N A R T E L A V R Y N D I S P L E N H H C A V A F Q I L A E P E C N I F S N I P P D G F K Q I R Q G M I T L I L A T D M A R H A E I M D S F K E K M E N F D Y S N E E H M T L L K M I L I K C C D I S N E V R P M E V A E P W V D C L L E E Y F M Q S D R E K S E G L P V A P F M D R D K V T K A T A Q I G F I K F V L I P M F E T V T K L F P M V E E I M L Q P L W E S R D R Y E E L K R I D D A M K E L Q K K T D S L T S G A T E K S R E R S R D V K N S E G D C A
Cofactor	COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:19919087, ECO:0000269|PubMed:20121115, ECO:0000269|PubMed:21483814, ECO:0000269|PubMed:22985069, ECO:0000269|PubMed:23025719, ECO:0000305|PubMed:18757755}; Note=Binds 1 Zn(2+) ion per subunit. Binds 2 divalent metal cations per subunit: site 1 preferentially binds zinc, while site 2 has a preference for magnesium. Tightly binds zinc. {ECO:0000269|PubMed:19919087, ECO:0000269|PubMed:20121115, ECO:0000269|PubMed:21483814, ECO:0000269|PubMed:22985069, ECO:0000269|PubMed:23025719, ECO:0000305|PubMed:18757755}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:19919087, ECO:0000269|PubMed:20121115, ECO:0000269|PubMed:21483814, ECO:0000269|PubMed:22985069, ECO:0000269|PubMed:23025719, ECO:0000305|PubMed:18757755}; Note=Binds 1 Mg(2+) ions per subunit. Binds 2 divalent metal cations per subunit: site 1 preferentially binds zinc, while site 2 has a preference for magnesium. Binds magnesium less tightly than zinc. {ECO:0000269|PubMed:19919087, ECO:0000269|PubMed:20121115, ECO:0000269|PubMed:21483814, ECO:0000269|PubMed:22985069, ECO:0000269|PubMed:23025719, ECO:0000305|PubMed:18757755};
Active site	ACT_SITE 312 312 Proton donor. {ECO:0000269|PubMed:18757755}.
Pfam	PF00233
InterPro	IPR003607 IPR023088 IPR002073 IPR036971 IPR023174