Uniprot ID	O88502
Uniprot Name	PDE8A_MOUSE
Taxonomy ID	10090
Sequence	M G C A P S I H T S E N R T F S H S D G E D E D V D V D V P G P A P R S I Q R W S T A P G L V E P Q P R D N G A S K V S V A D V Q F G P M R F H Q D Q L Q V L L V F T K E D S Q C N G F H R A C E K A G F K C T V T K E V Q T V L T C F Q D K L H D I I I I D H R Y P R Q M D A E T L C R S I R S S K F S E N T V I V G V V R R V D K E E S S L M P F L A A G F T R R F I E N P N V M A C Y N E L L Q L A C G E V R S Q L K L R A C N S V F T A L E K S Q E A I E I T S E D H I I Q Y A N P A F E S T M G Y Q S G E L I G K E L A Q V P I N E K K G D L L D A I N S C V T V D K E W Q G V Y H T Q K K N G D N I Q Q N V K I I P V I G Q G G K I R H Y V S I I R V C N G N N K V E T T T E C V Q T D S Q T D N Q A G K H K D R R K H S M D A K A V S S R T S D V S S Q R R H S S L A R I H S M M I E A P I T K V I N I I N A A Q E N S P V P V T E A L N R V L D I L R T T E L Y S P Q F N A Q D D P H A T D L V G G L M S D G L R R F S G N E Y I L A T K N L P P L S N N L A T P V S L H D V P P R I A L A I E N E E Q W D F D I F E L E V A T Q N R P L I Y L G L K T F A R F G M C E F L Q C S E T T L R S W F Q M I E S N Y H S S N P Y H N S T H A A D V L H A T A Y F L S R D K I K E T L D R I D E V A A L I A A T V H D V D H P G R T N S F L C N A G N Q L A V L Y N D T A V L E S H H V A L A F Q L T L E N D Q C N I F K Q M E R N D Y R T L R Q S I I D M V L A T E M T K H F E H V N K F I N S I N K P L T A Q E S E E P D R S L E D I K A M L K T P E S R A L I K R M M I K C A D V S N P C R P L E H C I E W A A R I S E E Y F S Q T D E E K Q L D L P V V M P V F D R N T C S I P K S Q I S F I D Y F I T D M F D A W D A F V D L P N L M Q H L D D N F R Y W K G L D E K K L R S L R P P P E
Cofactor	COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence={ECO:0000250}; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. {ECO:0000250};
Active site	ACT_SITE 551 551 Proton donor. {ECO:0000250|UniProtKB:O76083}.
Pfam	PF13426 PF00233
InterPro	IPR003607 IPR000014 IPR035965 IPR023088 IPR002073 IPR036971 IPR023174