Uniprot ID	O90368
Uniprot Name	POLN_ONNVS
Taxonomy ID	374989
Sequence	M D S V Y V D I D A D S A F L K A L Q R A Y P M F E V E P K Q V T P N D H A N A R A F S H L A I K L I E Q E I D P D S T I L D I G P A P A R R M M S D R K Y H C V C P M R S A E D P E R L A N Y A R K L A S A A G K V T D K N I S G K I N D L Q A V M A V P N M E T S T F C L H T D A T C K Q R G D V A I Y Q D V Y A V H A P T S L Y H Q A I K G V R V A Y W I G F D T T P F M Y N A M A G A Y P S Y S T N W A D E Q V L K A K N I G L C S T D L S E G R R G K L S I M R G K K L K P C D R V L F S V G S T L Y P E S R K L L Q S W H L P S V F H L K G K L S F T C R C D T I V S C E G Y V V K R V T M S P G I Y G K T S G Y A V T H H A D G F L M C K T T D T V D G E R V S F S V C T Y V P A T I C D Q M T G I L A T E V T P E D A Q K L L V G L N Q R I V V N G R T Q R N T N T M K N Y L L P I V A Q A F S K W A K E C R K D M E D E K L L G V R E R T L T C C C L W A F R K H K T H T V Y K R P D T Q S I Q K V P A E F D S F V I P S L W S S G L S I P L R T R I K W L L S K A P K H E Q L P H S G N A E E A A Q A E M D A A E E R E A E L T R E A M P P L Q A T Q D D V Q V E I D V E Q L E D R A G A G I V E T P R G A I K V T A Q P S D R V V G E Y L V L T P Q A V L R S Q K L S L I H A L A E Q V K T C T H S G R A G R Y A V E A Y D G R V L V P S G Y A I P Q E D F Q S L S E S A T M V F N E R E F V N R K L H H I A M H G P A L N T D E E S Y E L V R V E K T E H E Y V Y D V D Q K K C C K R E E A T G L V L V G D L T S P P Y H E F A Y E G L K I R P A C P Y K T A V I G V F G V P G S G K S A I I K N L V T R Q D L V T S G K K E N C Q E I S N D V M R Q R K L E I S A R T V D S L L L N G C N K P V E V L Y V D E A F A C H S G T L L A L I A M V R P R Q K V V L C G D P K Q C G F F N M M Q M K V N Y N H N I C T Q V Y H K S I S R R C T L P V T A I V S S L H Y E S K M R T T N E Y N Q P I V V D T T G I T K P E P G D L V L T C F R G W V K Q L Q I D Y R G N E V M T A A A S Q G L T R K G V Y A V R Q K V N E N P L Y A S T S E H V N V L L T R T E G K L I W K T L S G D P W I K I L Q N P P K G N F K A T I K E W E A E H A S I M A G I C N H Q M A F D T F Q N K A N V C W A K C L V P I L D T A G I K L S D R Q W S Q I V Q A F K E D R A Y S P E V A L N E I C T R I Y G V D L D S G L F S K P L I S V Y Y A D N H W D N R P G G K M F G F N P E V A L M L E K K Y P F T K G K W N I N K Q I C I T T R K V D E F N P E T N I I P A N R R L P H S L V A E H H T V R G E R M E W L V N K I N G H H M L L V S G Y N L I L P T K R V T W V A P L G T R G A D Y T Y N L E L G L P A T L G R Y D L V V I N I H T P F R I H H Y Q Q C V D H A M K L Q M L G G D S L R L L K P G G S L L I R A Y G Y A D R T S E R V I S V L G R K F R S S R A L K P Q C I T S N T E M F F L F S R F D N G R R N F T T H V M N N Q L N A V Y A G L A T R A G C A P S Y R V K R M D I A K N T E E C V V N A A N P R G V P G D G V C K A V Y R K W P E S F R N S A T P V G T A K T I M C G Q Y P V I H A V G P N F S N Y S E A E G D R E L A S V Y R E V A K E V S R L G V S S V A I P L L S T G V Y S G G K D R L L Q S L N H L F T A M D S T D A D V V I Y C R D K E W E K K I T E A I S L R S Q V E L L D D H I S V D C D I V R V H P D S S L A G R K G Y S T V E G A L Y S Y L E G T R F H Q T A V D M A E I Y T M W P K Q T E A N E Q V C L Y A L G E S I E S V R Q K C P V D D A D A S F P P K T V P C L C R Y A M T P E R V A R L R M N H T T S I I V C S S F P L P K Y K I E G V Q K V K C S K A L L F D H N V P S R V S P R T Y R P A D E I I Q T P Q I P T E A C Q D A Q F V Q S I T D E A V P V P S D L E A C D A T M D W P S I D I V P T R Q R S D S F D S E Y S S R S N I Q L V T A D V H A P M Y A N S L A S S G G S V L S L S S E Q A Q N G I M I L P D S E D T D S I S R V S T P I A P P R R R L G R T I N V T C D E R E G K I L P M A S D R L F T A K P Y T V A L G V S T A D I T A Y P I Q A P L G S T Q P P A L E Q I T F G D F A E G E I D N L L T G A L T F G D F E P G E V E E L T D S E W S T C S D T D E E L X L D R A G G Y I F S S D T G Q G H L Q Q K S V R Q T T L P V N I V E E V H E E K C Y P P K L D E I K E Q L L L K R L Q E S A S T A N R S R Y Q S R K V E N M K A T I I H R L K E G C R L Y L A S D T P R V P S Y R I T Y P A P V Y S P S I S I K L N N P E T A V A V C N E F L A R N Y P T V A S Y Q V T D E Y D A Y L D M V D G S E S C L D R A T F N P S K L R S Y P K Q H S Y H A P T I R S A V P S P F Q N T L Q N V L A A A T K R N C N V T Q M R E L P T M D S A V F N V E C F K K Y A C N Q E Y W R E F A S S P I R V T T E N L T M Y V T K L K G P K A A A L F A K T H N L L P L Q E V P M D R F T M D M K R D V K V T P G T K H T E E R P K V Q V I Q A A E P L A T A Y L C G I H R E L V R R L N A V L L P N V H T L F D M S A E D F D A I I S T H F K P G D A V L E T D I A S F D K S Q D D S L A L T A M M L L E D L G V D Q P I L D L I E A A F G E I S S C H L P T G T R F K F G A M M K S G M F L T L F V N T L L N I T I A S R V L E E R L T T S A C A A F I G D D N I I H G V V S D A L M A A R C A T W M N M E V K I I D A V V S E K A P Y F C G G F I L H D T V T G T S C R V A D P L K R L F K L G K P L A A G D E Q D E D R R R A L A D E V T R W Q R T G L I T E L E K A V Y S R Y E V Q G I T A V I T S M A T F A S S K E N F K K L R G P V V T L Y G G P K
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P03317}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:P03317}; Note=For nsP4 adenylyltransferase activity; Mn(2+) supports catalysis at 60% of the levels observed with Mg(2+). {ECO:0000250|UniProtKB:P03317}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP4 RNA-directed RNA polymerase activity. {ECO:0000250|UniProtKB:P03317}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P27282}; Note=For nsP1 guanylylation. {ECO:0000250|UniProtKB:P27282}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 RNA triphosphatase activity. {ECO:0000250|UniProtKB:Q8JUX6}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 NTPase activity. {ECO:0000250|UniProtKB:Q8JUX6};
Active site	ACT_SITE 1013 1013 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.; ACT_SITE 1083 1083 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.
Pfam	PF01661 PF01707 PF00978 PF01443 PF01660
InterPro	IPR027351 IPR002588 IPR002620 IPR002589 IPR027417 IPR007094 IPR001788