Uniprot ID	O93794
Uniprot Name	TOP2_CANGA
Taxonomy ID	284593
Sequence	M S E P K T A S E R Y Q K I S Q L E H I L K R P D T Y I G S V E I Q E Q E Q W I Y D E E T D C M I D K T V N I V P G L F K I F D E I L V N A A D N K V R D P S M K R I D V T I N P E E N F I E V R N D G K G I P I E I H E K E K I Y I P E L I F G H L L T S S N Y D D D E K K V T G G R N G Y G A K L C N I F S T E F T L E T A D P K N G R K Y V Q T W E N N M N V C H P P K I T S Y K K G P S Y T K V A F K P D L S R F G M E S L D S D I L G V M R R R V Y D I N G S V R D V N V Y L N G K P L K I R N F K N Y V E L Y L K S L E K M R K M D N G E S D T T P S N I P T I L Y E R V S D R W E I A F A V S D I S F K Q V S F V N S I A T T T G G T H V N Y I A D Q I V R K V S D I L K K K K K N I K P Y Q I K N N M F I F I N C L I E N P A F T S Q T K E Q L T T R V K D F G S R C D I S S D Y I N K I M K T D L A T K I F E I A D E N A N N A L K K S D G S R K S R I T D Y P K L E D A N K A G T K D G Y K C T L I L T E G D S A L S L A V A G L A V V G R D Y Y G C Y P L R G K M L N V R E A T A D Q I L K N A E I Q A I K K I M G L Q H R K K Y E D T K S L R Y G H L M I M T D Q D H D G S H I K G L I I N F I E T S F P G L L D I P G F L I E F I T P I V K V T I T K P I K K V I S F F N L P D Y E K W R E E E S H K Y S W K Q K Y Y K G L G T S T S P E I I E Y F S N L D T H L K K F H A L Q G D D K D L I D L A F S K K K A D D R K E W L R Q Y E P G T V L D P T L N E I P I S D F I N K E L I L F S L A D N V R S I P S V L D G F K P G Q R K V L Y T C F K K N L T T E K K V A N L A P A V S D Y T A Y H H G E Q A L V Q T I I G M A Q N F V G T N N I Y F L K P N G A F G T R A T G G K D A A A A R Y I Y T E L N K I A R K V F H P A D D P L F R Y V Q E D E K T V E P E W Y L P V V P M V L I N G A E G I G T G W S T S I P P F N P L D V V N N I R H L L N D E E M D D M H P W F R G W T G T M E K I E S Q R Y R M Y G R I E Q V G P N T L E I T E L P A R T W T S T I K E H L L L G L G G S E K V K P W I K D M E E Q H A E T I K F I I K L T D E E M T K T R K L G F Y E R F K L I S P I S L Q N M V A F D Y R G K I K K Y D H V H E I L K D F Y E V R L E Y Y Q K R K D Y M T G R L Q W E A E K L S F Q V K F I K M I I D K S L I V T N K P K K Q L I S E L E E L G F P R I N K E G K P H F G K I D E E V E A I I S E D E D E D L E E S E E A T R K K D K D D E S T V N G P E E L F G T Y E Y L L G L K I W S L T K E R Y E K L L K Q K Q E K E T E L E N L L K L S A K D L W N N D L D D F L T A Y E D F Q K M D L F L R N S A V P K T K G G K R K R K G G D D D D Y D P S G K K K P A R R I K K I K K E D D F D R I L I K P Q A K I K A K R P V K V K V E P P S S A A S T P S V K E E L G V S D V T S N A S T P S T T I F D Q K V K Q E N S D E S G I S A F S S K F N K I A S A F D E D A P L D Q I T S E D T S V K E S S A P A A K K K A P P K R K A K V V E S S E D E L S D A N L S E Q D D E E V V P V R R Q R S S R Q T A K K S Y A E P I E I S D E E D F I D D D E D E E V D S D E S F N D E
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 780 780 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250|UniProtKB:P06786}.
Pfam	PF00204 PF00521 PF02518 PF01751 PF16898
InterPro	IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013757 IPR013759 IPR013506 IPR018522 IPR031660 IPR006171 IPR034157