Uniprot ID	O94039
Uniprot Name	TKT1_CANAX
Taxonomy ID	5476
Sequence	M P S L D E L T I S T I R G L S V D A V S A A N S G H P G A P L G L A P A A H V V W Q K M K F N P K D P N W I N R D R F V L S N G H A C A L L Y S L L V L Y K F E L T V D D L K Q F R Q L G F K T P G H P E A T D T A G V E V T T G P L G Q G I S N A V G I A I A Q K Q F A A T Y N K P D I T L S D S Y V Y T F V G D G C L M E G V S S E T S S L A G H L Q L N N L I A F W D D N R I S I D G D T A V S F T E N V P D R Y R A Y G W N V L E V P D A N T N I E A I A A A V D E A K K S T D K P T L I R L V T T I G Y G S L K Q G S H D V H G S P L K P D D I K Q L K K S W G F K E D V D F F I P E E V S E Y L A K H V S E N Q K V Q K E W E A K L A E Y K K K Y P T E G A E I Q R R L D G K L P E G W K E Y L P K Y T P A D K P L A T R K L S E N V I N A L H G K I P E F I G G S A D L T G S N L T R A E G S V D F Q P P S T G L G N Y D G V Y I R Y G V R E H G M G A I M N G I A A F G A N Y K N Y G G T F L N F V S Y A A G A L R L S A L S H H P V I W V A T H D S I G L G E D G P T H Q P I E T L A H F R A I P N L S V W R P A D G N E V S A A Y A A A I E S T S H P S V I A L T R Q N L P Q L E G S S I E N A L K G G Y T L V K K D N P D V I I V S S G S E V S I S V A A S E E L A K Q G V K A N V V S L P D F F T F D Q Q S D E Y R L S V L P D G V P I L S V E V M S T F G W S K Y S H E Q F G L N R F G A S G K A A D L Y K Y F E F T P E G I A E R A Q K T I K Y Y E G K Q L L S P L D R A F
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000250}; Note=Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). {ECO:0000250}; COFACTOR: Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO:0000250};
Active site	ACT_SITE 415 415 Proton donor. {ECO:0000250}.
Pfam	PF02779 PF02780 PF00456
InterPro	IPR029061 IPR009014 IPR005475 IPR005478 IPR020826 IPR033248 IPR033247 IPR005474