Uniprot ID	O95263
Uniprot Name	PDE8B_HUMAN
Taxonomy ID	9606
Sequence	M G C A P S I H V S Q S G V I Y C R D S D E S S S P R Q T T S V S Q G P A A P L P G L F V Q T D A A D A I P P S R A S G P P S V A R V R R A R T E L G S G S S A G S A A P A A T T S R G R R R H C C S S A E A E T Q T C Y T S V K Q V S S A E V R I G P M R L T Q D P I Q V L L I F A K E D S Q S D G F W W A C D R A G Y R C N I A R T P E S A L E C F L D K H H E I I V I D H R Q T Q N F D A E A V C R S I R A T N P S E H T V I L A V V S R V S D D H E E A S V L P L L H A G F N R R F M E N S S I I A C Y N E L I Q I E H G E V R S Q F K L R A C N S V F T A L D H C H E A I E I T S D D H V I Q Y V N P A F E R M M G Y H K G E L L G K E L A D L P K S D K N R A D L L D T I N T C I K K G K E W Q G V Y Y A R R K S G D S I Q Q H V K I T P V I G Q G G K I R H F V S L K K L C C T T D N N K Q I H K I H R D S G D N S Q T E P H S F R Y K N R R K E S I D V K S I S S R G S D A P S L Q N R R Y P S M A R I H S M T I E A P I T K V I N I I N A A Q E N S P V T V A E A L D R V L E I L R T T E L Y S P Q L G T K D E D P H T S D L V G G L M T D G L R R L S G N E Y V F T K N V H Q S H S H L A M P I T I N D V P P C I S Q L L D N E E S W D F N I F E L E A I T H K R P L V Y L G L K V F S R F G V C E F L N C S E T T L R A W F Q V I E A N Y H S S N A Y H N S T H A A D V L H A T A F F L G K E R V K G S L D Q L D E V A A L I A A T V H D V D H P G R T N S F L C N A G S E L A V L Y N D T A V L E S H H T A L A F Q L T V K D T K C N I F K N I D R N H Y R T L R Q A I I D M V L A T E M T K H F E H V N K F V N S I N K P M A A E I E G S D C E C N P A G K N F P E N Q I L I K R M M I K C A D V A N P C R P L D L C I E W A G R I S E E Y F A Q T D E E K R Q G L P V V M P V F D R N T C S I P K S Q I S F I D Y F I T D M F D A W D A F A H L P A L M Q H L A D N Y K H W K T L D D L K C K S L R L P S D S
Cofactor	COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence={ECO:0000250}; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. {ECO:0000250};
Active site	ACT_SITE 615 615 Proton donor. {ECO:0000250|UniProtKB:O76083}.
Pfam	PF13426 PF08629 PF00233
InterPro	IPR003607 IPR000014 IPR035965 IPR023088 IPR002073 IPR036971 IPR023174 IPR013938