Uniprot ID	P03317
Uniprot Name	POLN_SINDV
Taxonomy ID	11034
Sequence	M E K P V V N V D V D P Q S P F V V Q L Q K S F P Q F E V V A Q Q V T P N D H A N A R A F S H L A S K L I E L E V P T T A T I L D I G S A P A R R M F S E H Q Y H C V C P M R S P E D P D R M M K Y A S K L A E K A C K I T N K N L H E K I K D L R T V L D T P D A E T P S L C F H N D V T C N M R A E Y S V M Q D V Y I N A P G T I Y H Q A M K G V R T L Y W I G F D T T Q F M F S A M A G S Y P A Y N T N W A D E K V L E A R N I G L C S T K L S E G R T G K L S I M R K K E L K P G S R V Y F S V G S T L Y P E H R A S L Q S W H L P S V F H L N G K Q S Y T C R C D T V V S C E G Y V V K K I T I S P G I T G E T V G Y A V T H N S E G F L L C K V T D T V K G E R V S F P V C T Y I P A T I C D Q M T G I M A T D I S P D D A Q K L L V G L N Q R I V I N G R T N R N T N T M Q N Y L L P I I A Q G F S K W A K E R K D D L D N E K M L G T R E R K L T Y G C L W A F R T K K V H S F Y R P P G T Q T C V K V P A S F S A F P M S S V W T T S L P M S L R Q K L K L A L Q P K K E E K L L Q V S E E L V M E A K A A F E D A Q E E A R A E K L R E A L P P L V A D K G I E A A A E V V C E V E G L Q A D I G A A L V E T P R G H V R I I P Q A N D R M I G Q Y I V V S P N S V L K N A K L A P A H P L A D Q V K I I T H S G R S G R Y A V E P Y D A K V L M P A G G A V P W P E F L A L S E S A T L V Y N E R E F V N R K L Y H I A M H G P A K N T E E E Q Y K V T K A E L A E T E Y V F D V D K K R C V K K E E A S G L V L S G E L T N P P Y H E L A L E G L K T R P A V P Y K V E T I G V I G T P G S G K S A I I K S T V T A R D L V T S G K K E N C R E I E A D V L R L R G M Q I T S K T V D S V M L N G C H K A V E V L Y V D E A F A C H A G A L L A L I A I V R P R K K V V L C G D P M Q C G F F N M M Q L K V H F N H P E K D I C T K T F Y K Y I S R R C T Q P V T A I V S T L H Y D G K M K T T N P C K K N I E I D I T G A T K P K P G D I I L T C F R G W V K Q L Q I D Y P G H E V M T A A A S Q G L T R K G V Y A V R Q K V N E N P L Y A I T S E H V N V L L T R T E D R L V W K T L Q G D P W I K Q P T N I P K G N F Q A T I E D W E A E H K G I I A A I N S P T P R A N P F S C K T N V C W A K A L E P I L A T A G I V L T G C Q W S E L F P Q F A D D K P H S A I Y A L D V I C I K F F G M D L T S G L F S K Q S I P L T Y H P A D S A R P V A H W D N S P G T R K Y G Y D H A I A A E L S R R F P V F Q L A G K G T Q L D L Q T G R T R V I S A Q H N L V P V N R N L P H A L V P E Y K E K Q P G P V K K F L N Q F K H H S V L V V S E E K I E A P R K R I E W I A P I G I A G A D K N Y N L A F G F P P Q A R Y D L V F I N I G T K Y R N H H F Q Q C E D H A A T L K T L S R S A L N C L N P G G T L V V K S Y G Y A D R N S E D V V T A L A R K F V R V S A A R P D C V S S N T E M Y L I F R Q L D N S R T R Q F T P H H L N C V I S S V Y E G T R D G V G A A P S Y R T K R E N I A D C Q E E A V V N A A N P L G R P G E G V C R A I Y K R W P T S F T D S A T E T G T A R M T V C L G K K V I H A V G P D F R K H P E A E A L K L L Q N A Y H A V A D L V N E H N I K S V A I P L L S T G I Y A A G K D R L E V S L N C L T T A L D R T D A D V T I Y C L D K K W K E R I D A A L Q L K E S V T E L K D E D M E I D D E L V W I H P D S C L K G R K G F S T T K G K L Y S Y F E G T K F H Q A A K D M A E I K V L F P N D Q E S N E Q L C A Y I L G E T M E A I R E K C P V D H N P S S S P P K T L P C L C M Y A M T P E R V H R L R S N N V K E V T V C S S T P L P K H K I K N V Q K V Q C T K V V L F N P H T P A F V P A R K Y I E V P E Q P T A P P A Q A E E A P E V V A T P S P S T A D N T S L D V T D I S L D M D D S S E G S L F S S F S G S D N S I T S M D S W S S G P S S L E I V D R R Q V V V A D V H A V Q E P A P I P P P R L K K M A R L A A A R K E P T P P A S N S S E S L H L S F G G V S M S L G S I F D G E T A R Q A A V Q P L A T G P T D V P M S F G S F S D G E I D E L S R R V T E S E P V L F G S F E P G E V N S I I S S R S A V S F P L R K Q R R R R R S R R T E Y X L T G V G G Y I F S T D T G P G H L Q K K S V L Q N Q L T E P T L E R N V L E R I H A P V L D T S K E E Q L K L R Y Q M M P T E A N K S R Y Q S R K V E N Q K A I T T E R L L S G L R L Y N S A T D Q P E C Y K I T Y P K P L Y S S S V P A N Y S D P Q F A V A V C N N Y L H E N Y P T V A S Y Q I T D E Y D A Y L D M V D G T V A C L D T A T F C P A K L R S Y P K K H E Y R A P N I R S A V P S A M Q N T L Q N V L I A A T K R N C N V T Q M R E L P T L D S A T F N V E C F R K Y A C N D E Y W E E F A R K P I R I T T E F V T A Y V A R L K G P K A A A L F A K T Y N L V P L Q E V P M D R F V M D M K R D V K V T P G T K H T E E R P K V Q V I Q A A E P L A T A Y L C G I H R E L V R R L T A V L L P N I H T L F D M S A E D F D A I I A E H F K Q G D P V L E T D I A S F D K S Q D D A M A L T G L M I L E D L G V D Q P L L D L I E C A F G E I S S T H L P T G T R F K F G A M M K S G M F L T L F V N T V L N V V I A S R V L E E R L K T S R C A A F I G D D N I I H G V V S D K E M A E R C A T W L N M E V K I I D A V I G E R P P Y F C G G F I L Q D S V T S T A C R V A D P L K R L F K L G K P L P A D D E Q D E D R R R A L L D E T K A W F R V G I T G T L A V A V T T R Y E V D N I T P V L L A L R T F A Q S K R A F Q A I R G E I K H L Y G G P K
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:17005674}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:17005674}; Note=For nsP4 adenylyltransferase activity; Mn(2+) supports catalysis at 60% of the levels observed with Mg(2+). {ECO:0000269|PubMed:17005674}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:19036396}; Note=For nsP4 RNA-directed RNA polymerase activity. {ECO:0000269|PubMed:19036396}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P27282}; Note=For nsP1 guanylylation. {ECO:0000250|UniProtKB:P27282}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 RNA triphosphatase activity. {ECO:0000250|UniProtKB:Q8JUX6}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 NTPase activity. {ECO:0000250|UniProtKB:Q8JUX6};
Active site	ACT_SITE 1021 1021 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.; ACT_SITE 1098 1098 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.
Pfam	PF01661 PF01707 PF00978 PF01443 PF01660
InterPro	IPR027351 IPR002588 IPR002620 IPR002589 IPR027417 IPR007094 IPR029063 IPR001788