Uniprot ID	P03354
Uniprot Name	POL_RSVP
Taxonomy ID	11888
Sequence	M E A V I K V I S S A C K T Y C G K T S P S K K E I G A M L S L L Q K E G L L M S P S D L Y S P G S W D P I T A A L S Q R A M I L G K S G E L K T W G L V L G A L K A A R E E Q V T S E Q A K F W L G L G G G R V S P P G P E C I E K P A T E R R I D K G E E V G E T T V Q R D A K M A P E E T A T P K T V G T S C Y H C G T A I G C N C A T A S A P P P P Y V G S G L Y P S L A G V G E Q Q G Q G G D T P P G A E Q S R A E P G H A G Q A P G P A L T D W A R V R E E L A S T G P P V V A M P V V I K T E G P A W T P L E P K L I T R L A D T V R T K G L R S P I T M A E V E A L M S S P L L P H D V T N L M R V I L G P A P Y A L W M D A W G V Q L Q T V I A A A T R D P R H P A N G Q G R G E R T N L N R L K G L A D G M V G N P Q G Q A A L L R P G E L V A I T A S A L Q A F R E V A R L A E P A G P W A D I M Q G P S E S F V D F A N R L I K A V E G S D L P P S A R A P V I I D C F R Q K S Q P D I Q Q L I R T A P S T L T T P G E I I K Y V L D R Q K T A P L T D Q G I A A A M S S A I Q P L I M A V V N R E R D G Q T G S G G R A R G L C Y T C G S P G H Y Q A Q C P K K R K S G N S R E R C Q L C N G M G H N A K Q C R K R D G N Q G Q R P G K G L S S G P W P G P E P P A V S L A M T M E H K D R P L V R V I L T N T G S H P V K Q R S V Y I T A L L D S G A D I T I I S E E D W P T D W P V M E A A N P Q I H G I G G G I P M R K S R D M I E L G V I N R D G S L E R P L L L F P A V A M V R G S I L G R D C L Q G L G L R L T N L I G R A T V L T V A L H L A I P L K W K P D H T P V W I D Q W P L P E G K L V A L T Q L V E K E L Q L G H I E P S L S C W N T P V F V I R K A S G S Y R L L H D L R A V N A K L V P F G A V Q Q G A P V L S A L P R G W P L M V L D L K D C F F S I P L A E Q D R E A F A F T L P S V N N Q A P A R R F Q W K V L P Q G M T C S P T I C Q L V V G Q V L E P L R L K H P S L C M L H Y M D D L L L A A S S H D G L E A A G E E V I S T L E R A G F T I S P D K V Q R E P G V Q Y L G Y K L G S T Y V A P V G L V A E P R I A T L W D V Q K L V G S L Q W L R P A L G I P P R L M G P F Y E Q L R G S D P N E A R E W N L D M K M A W R E I V R L S T T A A L E R W D P A L P L E G A V A R C E Q G A I G V L G Q G L S T H P R P C L W L F S T Q P T K A F T A W L E V L T L L I T K L R A S A V R T F G K E V D I L L L P A C F R E D L P L P E G I L L A L K G F A G K I R S S D T P S I F D I A R P L H V S L K V R V T D H P V P G P T V F T D A S S S T H K G V V V W R E G P R W E I K E I A D L G A S V Q Q L E A R A V A M A L L L W P T T P T N V V T D S A F V A K M L L K M G Q E G V P S T A A A F I L E D A L S Q R S A M A A V L H V R S H S E V P G F F T E G N D V A D S Q A T F Q A Y P L R E A K D L H T A L H I G P R A L S K A C N I S M Q Q A R E V V Q T C P H C N S A P A L E A G V N P R G L G P L Q I W Q T D F T L E P R M A P R S W L A V T V D T A S S A I V V T Q H G R V T S V A V Q H H W A T A I A V L G R P K A I K T D N G S C F T S K S T R E W L A R W G I A H T T G I P G N S Q G Q A M V E R A N R L L K D R I R V L A E G D G F M K R I P T S K Q G E L L A K A M Y A L N H F E R G E N T K T P I Q K H W R P T V L T E G P P V K I R I E T G E W E K G W N V L V W G R G Y A A V K N R D T D K V I W V P S R K V K P D I T Q K D E V T K K D E A S P L F A G I S D W I P W E D E Q E G L Q G E T A S N K Q E R P G E D T L A A N E S
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=The RT polymerase active site binds 2 magnesium ions. {ECO:0000255|PROSITE-ProRule:PRU00405}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 2 magnesium ions for ribonuclease H (RNase H) activity. Substrate-binding is a precondition for magnesium binding. {ECO:0000250}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:10669607, ECO:0000269|PubMed:11024025}; Note=Binds 2 Mg(2+) ions per integrase homodimer. {ECO:0000250};
Active site	ACT_SITE 614 614 For protease activity; shared with dimeric partner. {ECO:0000255|PROSITE-ProRule:PRU10094}.
Pfam	PF00607 PF00552 PF02022 PF02813 PF00665 PF00077 PF00078 PF06817 PF00098
InterPro	IPR001969 IPR004028 IPR000721 IPR017856 IPR036862 IPR001037 IPR001584 IPR003308 IPR012344 IPR001995 IPR021109 IPR034170 IPR018061 IPR008916 IPR008919 IPR010999 IPR012337 IPR002156 IPR036397 IPR000477 IPR010661 IPR001878 IPR036875