Uniprot ID	P03356
Uniprot Name	POL_MLVAV
Taxonomy ID	11791
Sequence	M G Q T V T T P L S L T L E H W E D V Q R I A S N Q S V D V K K R R W V T F C S A E W P T F G V G W P Q D G T F N L D I I L Q V K S K V F S P G P H G H P D Q V P Y I V T W E A I A Y E P P P W V K P F V S P K L S P S P T A P I L P S G P S T Q P P P R S A L Y P A L T P S I K P R P S K P Q V L S D N G G P L I D L L S E D P P P Y G G Q G L S S S D G D G D R E E A T S T S E I P A P S P I V S R L R G K R D P P A A D S T T S R A F P L R L G G N G Q L Q Y W P F S S S D L Y N W K N N N P S F S E D P G K L T A L I E S V L T T H Q P T W D D C Q Q L L G T L L T G E E K Q R V L L E A R K A V R G N D G R P T Q L P N E V D A A F P L E R P D W D Y T T Q R G R N H L V L Y R Q L L L A G L Q N A G R S P T N L A K V K G I T Q G P N E S P S A F L E R L K E A Y R R Y T P Y D P E D P G Q E T N V S M S F I W Q S A P D I G R K L E R L E D L K S K T L G D L V R E A E R I F N K R E T P E E R E E R V R R E T E E K E E R R R A E E E Q K E K E R D R R R H R E M S K L L A T V V S G Q R Q D R Q G G E R R R P Q L D K D Q C A Y C K E K G H W A K D C P K K P R G P R G P R P Q T S L L T L D D Q G G Q G Q E P P P E P R I T L T V G G Q P V T F L V D T G A Q H S V L T Q N P G P L S D R S A W V Q G A T G G K R Y R W T T D R K V H L A T G K V T H S F L H V P D C P Y P L L G R D L L T K L K A Q I H F E G S G A Q V V G P K G Q P L Q V L T L N L E D E Y R L Y E T S A E P E V S P G S T W L S D F P Q A W A E T G G M G L A V R Q A P L I I P L K A T S T P V S I K Q Y P M S Q E A K L G I K P H I Q R L L D Q G I L V P C Q S P W N T P L L P V K K P G T N D Y R P V Q D L R E V N K R V E D I H P T V P N P Y N L L S G L P P S H R W Y T V L D L K D A F F C L R L H P T S Q P L F A F E W R D P G M G I S G Q L T W T R L P Q G F K N S P T L F D E A L H R D L A D F R I Q H P D L I L L Q Y V D D I L L A A T S E L D C Q Q G T R A L L L T L G N L G Y R A S A K K A Q L C Q K Q V K Y L G Y L L K E G Q R W L T E A R K E T V M G Q P T P K T P R Q L R E F L G T A G F C R L W I P G F A E M A A P L Y P L T K T G T L F N W G P D Q Q K A Y Q E I K Q A L L T A P A L G L P D L T K P F E L F V D E K Q G Y A K G V L T Q K L G P W R R P V A Y L S K K L D P V A A G W P P C L R M V A A I A V L R K D A G K L T M G Q P L V I L A P H A V E A L V K Q P P D R W L S N A R M T H Y Q A M L L D T D R V Q F G P V V A L N P A T L L P L P E E G A P H D C L E I L A E T H G T R P D L T D Q P I P D A D H T W Y T D G S S F L Q E G Q R K A G A A V T T E T E V I W A R A L P A G T S A Q R A E L I A L T Q A L K M A E G K R L N V Y T D S R Y A F A T A H I H G E I Y R R R G L L T S E G R E I K N K S E I L A L L K A L F L P K R L S I I H C L G H Q K G D S A E A R G N R L A D Q A A R E A A I K T P P D T S T L L I E D S T P Y T P A Y F H Y T E T D L K K L R E L G A T Y N Q S K G Y W V F Q G K P V M P D Q F V F E L L D S L H R L T H L G Y Q K M K A L L D R G E S P Y Y M L N R D K T L Q Y V A D S C T V C A Q V N A S K A K I G A G V R V R G H R P G S H W E I D F T E V K P G L Y G Y K Y L L V F V D T F S G W V E A F P T K R E T A R V V S K K L L E E I F P R F G M P Q V L G S D N G P A F T S Q V S Q S V A D L L G I D W K L H C A Y R P Q S S G Q V E R M N R T I K E T L T K L T L A A G T R D W V L L L P L A L Y R A R N T P G P H G L T P Y E I L Y G A P P P L V N F H D P D M S E L T N S P S L Q A H L Q A L Q T V Q R E I W K P L A E A Y R D Q L D Q P V I P H P F R I G D S V W V R R H Q T K N L E P R W K G P Y T V L L T T P T A L K V D G I S A W I H A A H V K A A T T P P I K P S W R V Q R S Q N P L K I R L T R G A P
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00405}; Note=The RT polymerase active site binds 2 magnesium ions. {ECO:0000255|PROSITE-ProRule:PRU00405}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P03355}; Note=Binds 1 magnesium ion for ribonuclease H (RNase H) activity. {ECO:0000250|UniProtKB:P03355}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P03355}; Note=Magnesium ions are required for integrase activity. Binds at least 1, maybe 2 magnesium ions. {ECO:0000250|UniProtKB:P03355};
Active site	ACT_SITE 565 565 Protease; shared with dimeric partner. {ECO:0000255|PROSITE-ProRule:PRU00275}.
Pfam	PF01140 PF01141 PF02093 PF18697 PF00075 PF17919 PF00665 PF00077 PF00078 PF00098 PF16721
InterPro	IPR001969 IPR000840 IPR036946 IPR039464 IPR002079 IPR003036 IPR001584 IPR040643 IPR001995 IPR021109 IPR018061 IPR008919 IPR010999 IPR012337 IPR002156 IPR036397 IPR000477 IPR041577 IPR001878 IPR036875