Uniprot ID	P06214
Uniprot Name	HEM2_RAT
Taxonomy ID	10116
Sequence	M H H Q S V L H S G Y F H P L L R A W Q T T P S T V S A T N L I Y P I F V T D V P D D V Q P I A S L P G V A R Y G V N Q L E E M L R P L V E A G L R C V L I F G V P S R V P K D E Q G S A A D S E D S P T I E A V R L L R K T F P T L L V A C D V C L C P Y T S H G H C G L L S E N G A F L A E E S R Q R L A E V A L A Y A K A G C Q V V A P S D M M D G R V E A I K A A L L K H G L G N R V S V M S Y S A K F A S C F Y G P F R D A A Q S S P A F G D R R C Y Q L P P G A R G L A L R A V A R D I Q E G A D I L M V K P G L P Y L D M V Q E V K D K H P E L P L A V Y Q V S G E F A M L W H G A K A G A F D L R T A V L E S M T A F R R A G A D I I I T Y F A P Q L L K W L K E E
Cofactor	COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 8 zinc ions per octamer. Requires four zinc ions per octamer for full catalytic activity. Can bind up to 2 zinc ions per subunit. {ECO:0000250};
Active site	ACT_SITE 199 199 Schiff-base intermediate with substrate. {ECO:0000250}.; ACT_SITE 252 252 Schiff-base intermediate with substrate. {ECO:0000250}.
Pfam	PF00490
InterPro	IPR001731 IPR030656 IPR013785