Uniprot ID	P08096
Uniprot Name	TOP2_SCHPO
Taxonomy ID	284812
Sequence	M S I D A D F S D Y E D E A S G D E N V L P N T T T K R K A S T T S S K S R A K K A S T P D L R Q T S L T S M T A S E Q I P L V T N N G N G N S N V S T Q Y Q R L T P R E H V L R R P D T Y I G S I E P T T S E M W V F D S E K N K L D Y K A V T Y V P G L Y K I F D E I I V N A A D N K V R D P N M N T L K V T L D P E A N V I S I Y N N G K G I P I E I H D K E K I Y I P E L I F G N L L T S S N Y D D N Q K K V T G G R N G Y G A K L C N I F S T E F V V E T A D K E R M K K Y K Q T W Y D N M S R K S E P V I T S L K K P D E Y T K I T F K P D L A K F G M D K I D D D M V S I I K R R I Y D M A G T V R E T K V Y L N N E R I S I S G F K K Y V E M Y L A S D T K P D E E P P R V I Y E H V N D R W D V A F A V S D G Q F K Q V S F V N N I S T I R G G T H V N Y V A N K I V D A I D E V V K K E N K K A P V K A F Q I K N Y V Q V F V N C Q I E N P S F D S Q T K E T L T T K V S A F G S Q C T L S D K F L K A I K K S S V V E E V L K F A T A K A D Q Q L S K G D G G L R S R I T G L T K L E D A N K A G T K E S H K C V L I L T E G D S A K S L A V S G L S V V G R D Y Y G V F P L R G K L L N V R E A S H S Q I L N N K E I Q A I K K I M G F T H K K T Y T D V K G L R Y G H L M I M T D Q D H D G S H I K G L I I N Y L E S S Y P S L L Q I P G F L I Q F I T P I I K C T R G N Q V Q A F Y T L P E Y E Y W K E A N N N G R G W K I K Y Y K G L G T S D H D D M K S Y F S D L D R H M K Y F H A M Q E K D A E L I E M A F A K K K A D V R K E W L R T Y R P G I Y M D Y T Q P Q I P I D D F I N R E L I Q F S M A D N I R S I P S V V D G L K P G Q R K V V Y Y C F K R N L V H E T K V S R L A G Y V A S E T A Y H H G E V S M E Q T I V N L A Q N F V G S N N I N L L M P N G Q F G T R S E G G K N A S A S R Y L N T A L S P L A R V L F N S N D D Q L L N Y Q N D E G Q W I E P E Y Y V P I L P M V L V N G A E G I G T G W S T F I P N Y N P K D I T A N L R H M L N G E P L E I M T P W Y R G F R G S I T K V A P D R Y K I S G I I N Q I G E N K V E I T E L P I R F W T Q D M K E Y L E A G L V G T E K I R K F I V D Y E S H H G E G N V H F N V T L T E A G M K E A L N E S L E V K F K L S R T Q A T S N M I A F D A S G R I K K Y D S V E D I L T E F Y E V R L R T Y Q R R K E H M V N E L E K R F D R F S N Q A R F I H M I I E G E L V V S K K K K K D L I V E L K E K K F Q P I S K P K K G H L V D L E V E N A L A E E E Q S G D V S Q D E D S D A Y N Y L L S M P L W S L T Y E R Y V E L L K K K D E V M A E L D A L I K K T P K E L W L H D L D A F E H A W N K V M D D I Q R E M L E E E Q S S R D F V N R T K K K P R G K S T G T R K P R A I A G S S S S T A V K K E A S S E S K P S T T N R K Q Q T L L E F A A S K E P E K S S D I N I V K T E D N S H G L S V E E N R I S K S P G L D S S D S G K S R K R S Q S V D S E D A G S K K P V K K I A A S A S G R G R K T N K P V A T T I F S S D D E D D L L P S S L K P S T I T S T K A S A K N K G K K A S S V K K Q S P E D D D D D F I I P G S S S T P K A S S T N A E P P E D S D S P I R K R P T R R A A A T V K T P I Y V D P S F D S M D E P S M Q D D S F I V D N D E D V D D Y D E S D
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 835 835 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250|UniProtKB:P06786}.
Pfam	PF00204 PF00521 PF02518 PF01751 PF16898
InterPro	IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013757 IPR013759 IPR013506 IPR018522 IPR031660 IPR006171 IPR034157