Uniprot ID	P08411
Uniprot Name	POLN_SFV
Taxonomy ID	11033
Sequence	M A A K V H V D I E A D S P F I K S L Q K A F P S F E V E S L Q V T P N D H A N A R A F S H L A T K L I E Q E T D K D T L I L D I G S A P S R R M M S T H K Y H C V C P M R S A E D P E R L V C Y A K K L A A A S G K V L D R E I A G K I T D L Q T V M A T P D A E S P T F C L H T D V T C R T A A E V A V Y Q D V Y A V H A P T S L Y H Q A M K G V R T A Y W I G F D T T P F M F D A L A G A Y P T Y A T N W A D E Q V L Q A R N I G L C A A S L T E G R L G K L S I L R K K Q L K P C D T V M F S V G S T L Y T E S R K L L R S W H L P S V F H L K G K Q S F T C R C D T I V S C E G Y V V K K I T M C P G L Y G K T V G Y A V T Y H A E G F L V C K T T D T V K G E R V S F P V C T Y V P S T I C D Q M T G I L A T D V T P E D A Q K L L V G L N Q R I V V N G R T Q R N T N T M K N Y L L P I V A V A F S K W A R E Y K A D L D D E K P L G V R E R S L T C C C L W A F K T R K M H T M Y K K P D T Q T I V K V P S E F N S F V I P S L W S T G L A I P V R S R I K M L L A K K T K R E L I P V L D A S S A R D A E Q E E K E R L E A E L T R E A L P P L V P I A P A E T G V V D V D V E E L E Y H A G A G V V E T P R S A L K V T A Q P N D V L L G N Y V V L S P Q T V L K S S K L A P V H P L A E Q V K I I T H N G R A G R Y Q V D G Y D G R V L L P C G S A I P V P E F Q A L S E S A T M V Y N E R E F V N R K L Y H I A V H G P S L N T D E E N Y E K V R A E R T D A E Y V F D V D K K C C V K R E E A S G L V L V G E L T N P P F H E F A Y E G L K I R P S A P Y K T T V V G V F G V P G S G K S A I I K S L V T K H D L V T S G K K E N C Q E I V N D V K K H R G L D I Q A K T V D S I L L N G C R R A V D I L Y V D E A F A C H S G T L L A L I A L V K P R S K V V L C G D P K Q C G F F N M M Q L K V N F N H N I C T E V C H K S I S R R C T R P V T A I V S T L H Y G G K M R T T N P C N K P I I I D T T G Q T K P K P G D I V L T C F R G W V K Q L Q L D Y R G H E V M T A A A S Q G L T R K G V Y A V R Q K V N E N P L Y A P A S E H V N V L L T R T E D R L V W K T L A G D P W I K V L S N I P Q G N F T A T L E E W Q E E H D K I M K V I E G P A A P V D A F Q N K A N V C W A K S L V P V L D T A G I R L T A E E W S T I I T A F K E D R A Y S P V V A L N E I C T K Y Y G V D L D S G L F S A P K V S L Y Y E N N H W D N R P G G R M Y G F N A A T A A R L E A R H T F L K G Q W H T G K Q A V I A E R K I Q P L S V L D N V I P I N R R L P H A L V A E Y K T V K G S R V E W L V N K V R G Y H V L L V S E Y N L A L P R R R V T W L S P L N V T G A D R C Y D L S L G L P A D A G R F D L V F V N I H T E F R I H H Y Q Q C V D H A M K L Q M L G G D A L R L L K P G G S L L M R A Y G Y A D K I S E A V V S S L S R K F S S A R V L R P D C V T S N T E V F L L F S N F D N G K R P S T L H Q M N T K L S A V Y A G E A M H T A G C A P S Y R V K R A D I A T C T E A A V V N A A N A R G T V G D G V C R A V A K K W P S A F K G A A T P V G T I K T V M C G S Y P V I H A V A P N F S A T T E A E G D R E L A A V Y R A V A A E V N R L S L S S V A I P L L S T G V F S G G R D R L Q Q S L N H L F T A M D A T D A D V T I Y C R D K S W E K K I Q E A I D M R T A V E L L N D D V E L T T D L V R V H P D S S L V G R K G Y S T T D G S L Y S Y F E G T K F N Q A A I D M A E I L T L W P R L Q E A N E Q I C L Y A L G E T M D N I R S K C P V N D S D S S T P P R T V P C L C R Y A M T A E R I A R L R S H Q V K S M V V C S S F P L P K Y H V D G V Q K V K C E K G L L F D P T V P S V V S P R K Y A A S T T D H S D R S L R G F D L D W T T D S S S T A S D T M S L P S L Q S C D I D S I Y E P M A P I V V T A D V H P E P A G I A D L A A D V H P E P A D H V D L E N P I P P P R P K R A A Y L A S R A A E R P V P A P R K P T P A P R T A F R N K L P L T F G D F D E H E V D A L A S G I T F G D F D D V L R L G R A G A Y I F S S D T G S G H L Q Q K S V R Q H N L Q C A Q L D A V E E E K M Y P P K L D T E R E K L L L L K M Q M H P S E A N K S R Y Q S R K V E N M K A T V V D R L T S G A R L Y T G A D V G R I P T Y A V R Y P R P V Y S P T V I E R F S S P D V A I A A C N E Y L S R N Y P T V A S Y Q I T D E Y D A Y L D M V D G S D S C L D R A T F C P A K L R C Y P K H H A Y H Q P T V R S A V P S P F Q N T L Q N V L A A A T K R N C N V T Q M R E L P T M D S A V F N V E C F K R Y A C S G E Y W E E Y A K Q P I R I T T E N I T T Y V T K L K G P K A A A L F A K T H N L V P L Q E V P M D R F T V D M K R D V K V T P G T K H T E E R P K V Q V I Q A A E P L A T A Y L C G I H R E L V R R L N A V L R P N V H T L F D M S A E D F D A I I A S H F H P G D P V L E T D I A S F D K S Q D D S L A L T G L M I L E D L G V D Q Y L L D L I E A A F G E I S S C H L P T G T R F K F G A M M K S G M F L T L F I N T V L N I T I A S R V L E Q R L T D S A C A A F I G D D N I V H G V I S D K L M A E R C A S W V N M E V K I I D A V M G E K P P Y F C G G F I V F D S V T Q T A C R V S D P L K R L F K L G K P L T A E D K Q D E D R R R A L S D E V S K W F R T G L G A E L E V A L T S R Y E V E G C K S I L I A M A T L A R D I K A F K K L R G P V I H L Y G G P R L V R
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P03317}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:P03317}; Note=For nsP4 adenylyltransferase activity; Mn(2+) supports catalysis at 60% of the levels observed with Mg(2+). {ECO:0000250|UniProtKB:P03317}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P03317}; Note=For nsP4 RNA-directed RNA polymerase activity. {ECO:0000250|UniProtKB:P03317}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P27282}; Note=For nsP1 guanylylation. {ECO:0000250|UniProtKB:P27282}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 RNA triphosphatase activity. {ECO:0000250|UniProtKB:Q8JUX6}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 NTPase activity. {ECO:0000250|UniProtKB:Q8JUX6};
Active site	ACT_SITE 1015 1015 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.; ACT_SITE 1085 1085 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.
Pfam	PF01661 PF01707 PF00978 PF01443 PF01660
InterPro	IPR027351 IPR002588 IPR002620 IPR002589 IPR027417 IPR007094 IPR001788