Uniprot ID	P0A2I1
Uniprot Name	TOP1_SALTY
Taxonomy ID	99287
Sequence	M G K A L V I V E S P A K A K T I N K Y L G N D Y V V K S S V G H I R D L P T S G S A A K K S A D S T S T K T A K K P K K D E R G A L V N R M G V D P W H N W D A H Y E V L P G K E K V V S E L K Q L A E K A D H I Y L A T D L D R E G E A I A W H L R E V I G G D D A R Y S R V V F N E I T K N A I R Q A F E Q P G E L N I N R V N A Q Q A R R F M D R V V G Y M V S P L L W K K I A R G L S A G R V Q S V A V R L V V E R E R E I K A F V P E E F W E I D A N T T T P S G E A L P L Q V T H Q N D K P F R P V N R E Q T L A A V S L L E K A R Y S V L E R E D K P T S S K P G A P F I T S T L Q Q A A S T R L G F G V K K T M M M A Q R L Y E A G Y I T Y M R T D S T N L S Q D A V N M V R G Y I G D N F G K K Y L P D N P N Q Y A S K E N S Q E A H E A I R P S D V A V M A E S L K D M E A D A Q K L Y Q L I W R Q F V A C Q M T P A Q Y D S T T L T V G A G E F R L K A R G R I L R F D G W T K V M P A L R K G D E D R T L P A V N K G D A L T L L E L T P A Q H F T K P P A R F S E A S L V K E L E K R G I G R P S T Y A S I I S T I Q D R G Y V R V E N R R F Y A E K M G E I V T D R L E E N F R E L M N Y D F T A Q M E D S L D Q V A N H Q A E W K A V L D N F F S D F T Q Q L D K A E K D P E E G G M R P N Q M V L T S I D C P T C G R K M G I R T A S T G V F L G C S G Y A L S P K E R C K T T I N L V P E N E V L N V L E G D D A E T N A L R A K R R C Q K C G T A M D S Y L I D P K R K L H V C G N N P T C D G Y E I E E G E F R I K G Y D G P I V E C E K C G S E M H L K M G R F G K Y M A C T N D E C K N T R K I L R N G E V A P P K E D P V P L P E L P C E K S D A Y F V L R D G A A G I F L A A N T F P K S R E T R A P L V E E L Y R F R D R L P E K L R Y L A D A P Q Q D P E G N K T V V R F S R K T K Q Q Y V A A E K D G K A T G W S A F F V D G K W V E G K K
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_00952}; Note=Binds two Mg(2+) per subunit. {ECO:0000255|HAMAP-Rule:MF_00952};
Active site	ACT_SITE 319 319 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000255|HAMAP-Rule:MF_00952}.
Pfam	PF08272 PF01131 PF01751 PF01396
InterPro	IPR000380 IPR003601 IPR023406 IPR013497 IPR013824 IPR013825 IPR013826 IPR023405 IPR003602 IPR013498 IPR005733 IPR013263 IPR028612 IPR006171 IPR034149