Uniprot ID	P0A725
Uniprot Name	LPXC_ECOLI
Taxonomy ID	83333
Sequence	M I K Q R T L K R I V Q A T G V G L H T G K K V T L T L R P A P A N T G V I Y R R T D L N P P V D F P A D A K S V R D T M L C T C L V N E H D V R I S T V E H L N A A L A G L G I D N I V I E V N A P E I P I M D G S A A P F V Y L L L D A G I D E L N C A K K F V R I K E T V R V E D G D K W A E F K P Y N G F S L D F T I D F N H P A I D S S N Q R Y A M N F S A D A F M R Q I S R A R T F G F M R D I E Y L Q S R G L C L G G S F D C A I V V D D Y R V L N E D G L R F E D E F V R H K M L D A I G D L F M C G H N I I G A F T A Y K S G H A L N N K L L Q A V L A K Q E A W E Y V T F Q D D A E L P L A F K A P S A V L A
Cofactor	COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000255|HAMAP-Rule:MF_00388, ECO:0000269|PubMed:10026271, ECO:0000269|PubMed:20709752}; Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000269|PubMed:20136146, ECO:0000269|PubMed:20709752}; Note=Can use either Fe(2+) or Zn(2+). The metal cofactor can switch between Fe(2+) and Zn(2+) in response to metal availability. Metal switching may be important for regulating the LpxC activity upon changes in environmental conditions. Has a significantly higher affinity for Zn(2+), but exhibits higher activity with Fe(2+) (PubMed:20136146, PubMed:20709752). Can also use Co(2+), Ni(2+) and, to a lesser extent, Mn(2+) (PubMed:10026271). {ECO:0000269|PubMed:10026271, ECO:0000269|PubMed:20136146, ECO:0000269|PubMed:20709752};
Active site	ACT_SITE 265 265 Proton donor. {ECO:0000255|HAMAP-Rule:MF_00388, ECO:0000305|PubMed:15705580, ECO:0000305|PubMed:24108127}.
Pfam	PF03331
InterPro	IPR020568 IPR004463 IPR011334 IPR015870