Uniprot ID	P0C9C0
Uniprot Name	TOP2_ASFP4
Taxonomy ID	561443
Sequence	M E A F E I S D F K E H A K K K S M W A G A L N K V T I S G L M G V F T E D E D L M A L P I H R D H C P A L L K I F D E I I V N A T D H E R A C H S K T K K V T Y I K I S F D K G V F S C E N D G P G I P I A K H E Q A S L I A K R D V Y V P E V A S C H F L A G T N I N K A K D C I K G G T N G V G L K L A M V H S Q W A I L T T A D G A Q K Y V Q H I N Q R L D I I E P P T I T P S R E M F T R I E L M P V Y Q E L G Y A E P L S E T E Q A D L S A W I Y L R A C Q C A A Y V G K G T T I Y Y N D K P C R T G S V M A L A K M Y T L L S A P N S T I H T A T I K A D A K P Y S L H P L Q V A A V V S P K F K K F E H V S V I N G V N C V K G E H V T F L K K T I N E M V V K K F Q Q T I K D K N R K T T L R D S C S N I F I V I V G S I P G I E W T G Q R K D E L S I A E N V F K T H Y S I P S S F L T S M T K S I V D I L L Q S I S K K D N H K Q V D V D K Y T R A R N A G G K R A Q D C M L L A A E G D S A L S L L R T G L T L G K S N P S G P S F D F C G M I S L G G V I M N A C K K V T N I T T D S G E T I M V R N E Q L T N N K V L Q G I V Q V L G L D F N C H Y K T Q E E R A K L R Y G C I V A C V D Q D L D G C G K I L G L L L A Y F H L F W P Q L I I H G F V K R L L T P L I R V Y E K G K T V P V E F Y Y E Q E F D A W A K K Q T S L A N H T V K Y Y K G L A A H D T H E V K S M F K H F D N M V Y T F T L D D S A K E L F H I Y F G G E S E L R K R E L C T G V V P L T E T Q T Q S I H S V R R I P C S L H L Q V D T K A Y K L D A I E R Q I P N F L D G M T R A R R K I L A G G V K C F A S N N R E R K V F Q F G G Y V A D H M F Y H H G D M S L N T S I I K A A Q Y Y P G S S H L Y P V F I G I G S F G S R H L G G K D A G S P R Y I S V Q L A S E F I K T M F P A E D S W L L P Y V F E D G Q R A E P E Y Y V P V L P L A I M E Y G A N P S E G W K Y T T W A R Q L E D I L A L V R A Y V D K N N P K H E L L H Y A I K H K I T I L P L R P S N Y N F K G H L K R F G Q Y Y Y S Y G T Y V I S E Q R N I I T I T E L P L R V P T V A Y I E S I K K S S N R M T F I E E I I D Y S S S E T I E I L V K L K P N S L N R I M E E F K C T E E Q D S I E N F L R L R N C L H S H L N F V K P K G G I I E F N T Y Y E I L Y A W L P Y R R E L Y Q K R L M R E H A V L K L R I I M E T A I V R Y I N E S A E L N L S H Y E D E K E A S R I L S E H G F P P L N Q T L I I S P E F A S I E E L N Q K A L Q G C Y T Y I L S L Q A R E L L I A A K T R R V E K I K K M Q A R L D K V E Q L L Q E S P F P G A S V W L E E I D A V E K A I I K G R N T Q W K F H
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P11388}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:P11388}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250|UniProtKB:P11388}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000250|UniProtKB:P11388};
Active site	ACT_SITE 800 800 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250|UniProtKB:Q00942}.
Pfam	PF00521 PF02518 PF16898
InterPro	IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013757 IPR013759 IPR018522 IPR031660