Uniprot ID	P12531
Uniprot Name	TOP2_TRYBB
Taxonomy ID	5702
Sequence	M A E A H K Y K K L T P I E H V L T R P E M Y I G S L D T T A T P M F I Y D E Q K G H M V W E T V K L N H G L L K I V D E I L L N A S D N I S N R S A R M T Y I R V T I T D T G E I T I E N D G A G I P I V R S R E H K L Y I P E M V F G H L L T S S N Y D D D N Q N A V A G R H G Y G A K L T N I L S L S F S V C C R T N G R E F H M S W Q D H M R K A T A P R V S N V G T K E K N V T R V K F L P D Y E R F G M K E K K I S N D M K R V L Y K R I M D L S A M F P N I Q I T L N G S S F G F K S F K D Y A T L Y S A M T P K G E K P P P P Y V Y E S K S G C V A F I P S V V P G V R R M F G V V N G V V T Y N G G T H C N A A Q D I L T G C L D G V E R E L K K E N K V M D T N R V L R H F T I L V F L V Q V Q P K F D S Q N K A R L V S T P T M P R V P R Q D V M K Y L L R M P F L E A H V S T I T G Q L A Q E L N K E I G T G R R M S S K T L L T S I T K L V D A T S T R R D P K H T R T L I V T E G D S A K A L A Q N S L S S D Q K R Y T G V F P L R G K L L N V R N K N L K R L R N C K E L Q E L F C A L G L E L D K D Y T D A D E L R Y Q R I L I M T D Q D A D G S H I K G L V I N A F E S L W P S L L V R N P G F I S I F S T P I V K A R L R D K S V V S F F S M K E F H K W Q R S N A N T P Y T C K Y Y K G L G T S T T A E G K E Y F K D M E K H T M R L L V D R S D H K L L D N V F D S Q E V E W R K D W M T K A N A F T G E V D I D R S K K M L T V T D F V H K E M V H F A L V G N A R A L A H S V D G L K P S Q R K I I W A L M R R S G N E A A K V A Q L S G Y I S E A S A F H H G E T S L Q E T M I K M A Q S F T G G N N V N L L V P E G Q F G S R Q Q L G N D H A A P R Y I F T K L S K V A R L L F P S E D D P L L D Y I V E E G Q Q V E P N H Y V P I L P L L L C N G S V G I G F G F S S N I P P F H R L D V S A A V R A M I S G E R A K S V V R R L V P W A V G F Q G E I R R G P E G E F I A V G T Y T Y C K G G R V H V T E L P W T C S V E A F R E H I S Y L A T K D I V N R I A D Y S G A N H V D I D V E V A Q G A V N T Y A E C E S E L G L T Q R I H I N G T V F S P N G T L S P L E S D L T P V L Q W H Y D R R L D L Y K K R R Q R N L T L L E Q E L A R E K S T L K F V Q H F G A G H I D F A N A T E A T L E K V C S K L G L V R V D D S F D Y I L R K P I T F Y T K T S F E N L L K K I A E T E R R I E A L K K T T P V Q L W L G E L D Q F D R F F Q D H E K K M V E A I L K E R R Q R S P P S D L L P G L Q Q P R L E V E E A K G G K K F E M R V Q V R K Y V P P P T K R G A G G R S D G D G G A T A A G A A A A V G G R G E K K G P G R A G G V R R M V L D A L A K R V T R L L P R L L F
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 771 771 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250|UniProtKB:P06786}.
Pfam	PF00204 PF00521 PF02518 PF01751 PF16898
InterPro	IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013757 IPR013759 IPR013506 IPR018522 IPR031660 IPR006171 IPR034157