Uniprot ID	P14078
Uniprot Name	POL_HTL1C
Taxonomy ID	11927
Sequence	M G Q I F S R S A S P I P R P P R G L A A H H W L N F L Q A A Y R L E P G P S S Y D F H Q L K K F L K I A L E T P V W I C P I N Y S L L A S L L P K G Y P G R V N E I L H I L I Q T Q A Q I P S R P A P P P P S S S T H D P P D S D P Q I P P P Y V E P T A P Q V L P V M H P H G A P P N H R P W Q M K D L Q A I K Q E V S Q A A P G S P Q F M Q T I R L A V Q Q F D P T A K D L Q D L L Q Y L C S S L V A S L H H Q Q L D S L I S E A E T R G I T G Y N P L A G P L R V Q A N N P Q Q Q G L R R E Y Q Q L W L A A F A A L P G S A K D P S W A S I L Q G L E E P Y H A F V E R L N I A L D N G L P E G T P K D P I L R S L A Y S N A N K E C Q K L L Q A R G H T N S P L G D M L R A C Q A W T P K D K T K V L V V Q P K K P P P N Q P C F R C G K A G H W S R D C T Q P R P P P G P C P L C Q D P T H W K R D C P R L K P T I P E P E P E E D A L L L D L P A D I P H P K N L H R G G G L T S P P T L Q Q V L P N Q D P T S I L P V I P L D P A R R P V I K A Q I D T Q T S H P K T I E A L L D T G A D M T V L P I A L F S S N T P L K N T S V L G A G G Q T Q D H F K L T S L P V L I R L P F R T T P I V L T S C L V D T K N N W A I I G R D A L Q Q C Q G V L Y L P E A K R P P V I L P I Q A P A V L G L E H L P R P P E I S Q F P L N P E R L Q A L Q H L V R K A L E A G H I E P Y T G P G N N P V F P V K K A N G T W R F I H D L R A T N S L T I D L S S S S P G P P D L S S L P T T L A H L Q T I D L K D A F F Q I P L P K Q F Q P Y F A F T V P Q Q C N Y G P G T R Y A W R V L P Q G F K N S P T L F E M Q L A H I L Q P I R Q A F P Q C T I L Q Y M D D I L L A S P S H A D L Q L L S E A T M A S L I S H G L P V S E N K T Q Q T P G T I K F L G Q I I S P N H L T Y D A V P K V P I R S R W A L P E L Q A L L G E I Q W V S K G T P T L R Q P L H S L Y C A L Q R H T D P R D Q I Y L N P S Q V Q S L V Q L R Q A L S Q N C R S R L V Q T L P L L G A I M L T L T G T T T V V F Q S K Q Q W P L V W L H A P L P H T S Q C P W G Q L L A S A V L L L D K Y T L Q S Y G L L C Q T I H H N I S T Q T F N Q F I Q T S D H P S V P I L L H H S H R F K N L G A Q T G E L W N T F L K T T A P L A P V K A L M P V F T L S P V I I N T A P C L F S D G S T S Q A A Y I L W D K H I L S Q R S F P L P P P H K S A Q R A E L L G L L H G L S S A R S W R C L N I F L D S K Y L Y H Y L R T L A L G T F Q G R S S Q A P F Q A L L P R L L S R K V V Y L H H V R S H T N L P D P I S R L N A L T D A L L I T P V L Q L S P A D L H S F T H C G Q T A L T L Q G A T T T E A S N I L R S C H A C R K N N P Q H Q M P Q G H I R R G L L P N H I W Q G D I T H F K Y K N T L Y R L H V W V D T F S G A I S A T Q K R K E T S S E A I S S L L Q A I A Y L G K P S Y I N T D N G P A Y I S Q D F L N M C T S L A I R H T T H V P Y N P T S S G L V E R S N G I L K T L L Y K Y F T D K P D L P M D N A L S I A L W T I N H L N V L T N C H K T R W Q L H H S P R L Q P I P E T H S L S N K Q T H W Y Y F K L P G L N S R Q W K G P Q E A L Q E A A G A A L I P V S A S S A Q W I P W R L L K R A A C P R P V G G P A D P K E K D H Q H H G
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00405}; Note=The RT polymerase active site binds 2 magnesium ions. {ECO:0000255|PROSITE-ProRule:PRU00405}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 2 magnesium ions for ribonuclease H (RNase H) activity. {ECO:0000250};
Active site	ACT_SITE 481 481 Protease; shared with dimeric partner. {ECO:0000255|PROSITE-ProRule:PRU00275}.
Pfam	PF02228 PF00607 PF00552 PF02022 PF00075 PF00665 PF00077 PF00078 PF00098
InterPro	IPR001969 IPR003139 IPR036989 IPR000721 IPR036862 IPR001037 IPR001584 IPR003308 IPR001995 IPR021109 IPR018061 IPR008916 IPR008919 IPR010999 IPR012337 IPR002156 IPR036397 IPR000477 IPR001878 IPR036875