Uniprot ID	P15348
Uniprot Name	TOP2_DROME
Taxonomy ID	7227
Sequence	M E N G N K A L S I E Q M Y Q K K S Q L E H I L L R P D S Y I G S V E F T K E L M W V Y D N S Q N R M V Q K E I S F V P G L Y K I F D E I L V N A A D N K Q R D K S M N T I K I D I D P E R N M V S V W N N G Q G I P V T M H K E Q K M Y V P T M I F G H L L T S S N Y N D D E K K V T G G R N G Y G A K L C N I F S T S F T V E T A T R E Y K K S F K Q T W G N N M G K A S D V Q I K D F N G T D Y T R I T F S P D L A K F K M D R L D E D I V A L M S R R A Y D V A A S S K G V S V F L N G N K L G V R N F K D Y I D L H I K N T D D D S G P P I K I V H E V A N E R W E V A C C P S D R G F Q Q V S F V N S I A T Y K G G R H V D H V V D N L I K Q L L E V L K K K N K G G I N I K P F Q V R N H L W V F V N C L I E N P T F D S Q T K E N M T L Q Q K G F G S K C T L S E K F I N N M S K S G I V E S V L A W A K F K A Q N D I A K T G G R K S S K I K G I P K L E D A N E A G G K N S I K C T L I L T E G D S A K S L A V S G L G V I G R D L Y G V F P L R G K L L N V R E A N F K Q L S E N A E I N N L C K I I G L Q Y K K K Y L T E D D L K T L R Y G K V M I M T D Q D Q D G S H I K G L L I N F I H T N W P E L L R L P F L E E F I T P I V K A T K K N E E L S F Y S L P E F E E W K N D T A N H H T Y N I K Y Y K G L G T S T S K E A K E Y F Q D M D R H R I L F K Y D G S V D D E S I V M A F S K K H I E S R K V W L T N H M D E V K R R K E L G L P E R Y L Y T K G T K S I T Y A D F I N L E L V L F S N A D N E R S I P S L V D G L K P G Q R K V M F T C F K R N D K R E V K V A Q L S G S V A E M S A Y H H G E V S L Q M T I V N L A Q N F V G A N N I N L L E P R G Q F G T R L S G G K D C A S A R Y I F T I M S P L T R L I Y H P L D D P L L D Y Q V D D G Q K I E P L W Y L P I I P M V L V N G A E G I G T G W S T K I S N Y N P R E I M K N L R K M I N G Q E P S V M H P W Y K N F L G R M E Y V S D G R Y I Q T G N I Q I L S G N R L E I S E L P V G V W T Q N Y K E N V L E P L S N G T E K V K G I I S E Y R E Y H T D T T V R F V I S F A P G E F E R I H A E E G G F Y R V F K L T T T L S T N Q M H A F D Q N N C L R R F P T A I D I L K E Y Y K L R R E Y Y A R R R D F L V G Q L T A Q A D R L S D Q A R F I L E K C E K K L V V E N K Q R K A M C D E L L K R G Y R P D P V K E W Q R R I K M E D A E Q A D E E D E E E E E A A P S V S S K A K K E K E V D P E K A F K K L T D V K K F D Y L L G M S M W M L T E E K K N E L L K Q R D T K L S E L E S L R K K T P E M L W L D D L D A L E S K L N E V E E K E R A E E Q G I N L K T A K A L K G Q K S A S A K G R K V K S M G G G A G A G D V F P D P D G E P V E F K I T E E I I K K M A A A A K V A Q A A K E P K K P K E P K E P K V K K E P K G K Q I K A E P D A S G D E V D E F D A M V E G G S K T S P K A K K A V V K K E P G E K K P R Q K K E N G G G L K Q S K I D F S K A K A K K S D D D V E E V T P R A E R P G R R Q A S K K I D Y S S L F S D E E E D G G N V G S D D D G N A S D D D S P K R P A K R G R E D E S S G G A K K K A P P K K R R A V I E S D D D D I E I D E D D D D D S D F N C
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:1328202, ECO:0000269|PubMed:2547764, ECO:0000269|PubMed:6308011, ECO:0000269|PubMed:8383533}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:1328202, ECO:0000269|PubMed:8383533}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 785 785 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250|UniProtKB:P06786}.
Pfam	PF00204 PF00521 PF02518 PF01751 PF16898
InterPro	IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013757 IPR013759 IPR013506 IPR018522 IPR031660 IPR006171 IPR034157