Uniprot ID	P18096
Uniprot Name	POL_HV2BE
Taxonomy ID	11714
Sequence	M G A R N S V L R G K K A D E L E K V R L R P G G K K K Y R L K H I V W A A N E L D K F G L A E S L L E S K E G C Q K I L R V L D P L V P T G S E N L K S L F N T V C V I W C L H A E E K V K D T E E A K K L A Q R H L V A E T G T A E K M P N T S R P T A P P S G K R G N Y P V Q Q A G G N Y V H V P L S P R T L N A W V K L V E E K K F G A E V V P G F Q A L S E G C T P Y D I N Q M L N C V G D H Q A A M Q I I R E I I N E E A A D W D S Q H P I P G P L P A G Q L R D P R G S D I A G T T S T V D E Q I Q W M Y R P Q N P V P V G N I Y R R W I Q I G L Q K C V R K Y N P T N I L D I K Q G P K E P F Q S Y V D R F Y K S L R A E Q T D P A V K N W M T Q T L L I Q N A N P D C K L V L K G L G M N P T L E E M L T A C Q G V G G P G Q K A R L M A E A L K E A M G P S P I P F A A A Q Q R K A I R Y W N C G K E G H S A R Q C R A P R R Q G C W K C G K P G H I M A N C P E R Q A G F F R V G P T G K E A S Q L P R D P S P S G A D T N S T S G R S S S G T V G E I Y A A R E K A E G A E G E T I Q R G D G G L A A P R A E R D T S Q R G D R G L A A P Q F S L W K R P V V T A Y I E D Q P V E V L L D T G A D D S I V A G I E L G D N Y T P K I V G G I G G F I N T K E Y K N V E I K V L N K R V R A T I M T G D T P I N I F G R N I L T A L G M S L N L P V A K I E P I K V T L K P G K D G P R L K Q W P L T K E K I E A L K E I C E K M E K E G Q L E E A P P T N P Y N T P T F A I K K K D K N K W R M L I D F R E L N K V T Q D F T E I Q L G I P H P A G L A K K K R I S I L D V G D A Y F S I P L H E D F R Q Y T A F T L P A V N N M E P G K R Y I Y K V L P Q G W K G S P A I F Q Y T M R Q V L E P F R K A N P D V I L I Q Y M D D I L I A S D R T G L E H D K V V L Q L K E L L N G L G F S T P D E K F Q K D P P F Q W M G C E L W P T K W K L Q K L Q L P Q K D I W T V N D I Q K L V G V L N W A A Q I Y S G I K T K H L C R L I R G K M T L T E E V Q W T E L A E A E L E E N K I I L S Q E Q E G Y Y Y Q E E K E L E A T I Q K S Q G H Q W T Y K I H Q E E K I L K V G K Y A K I K N T H T N G V R L L A Q V V Q K I G K E A L V I W G R I P K F H L P V E R E T W E Q W W D N Y W Q V T W I P E W D F V S T P P L V R L T F N L V G D P I P G A E T F Y T D G S C N R Q S K E G K A G Y V T D R G K D K V K V L E Q T T N Q Q A E L E V F R M A L A D S G P K V N I I V D S Q Y V M G I V A G Q P T E S E N R I V N Q I I E E M I K K E A V Y V A W V P A H K G I G G N Q E V D H L V S Q G I R Q V L F L E K I E P A Q E E H E K Y H S I I K E L T H K F G I P L L V A R Q I V N S C A Q C Q Q K G E A I H G Q V N A E I G V W Q M D Y T H L E G K I I I V A V H V A S G F I E A E V I P Q E S G R Q T A L F L L K L A S R W P I T H L H T D N G P N F T S Q E V K M V A W W V G I E Q S F G V P Y N P Q S Q G V V E A M N H H L K N Q I S R I R E Q A N T I E T I V L M A V H C M N F K R R G G I G D M T P A E R L I N M I T T E Q E I Q F L Q R K N S N F K N F Q V Y Y R E G R D Q L W K G P G E L L W K G E G A V I V K V G T D I K V V P R R K A K I I R D Y G G R Q E L D S S P H L E G A R E D G E M A C P C Q V P E I Q N K R P R G G A L C S P P Q G G M G M V D L Q Q G N I P T T R K K S S R N T G I L E P N T R K R M A L L S C S K I N L V Y R K V L D R C Y P R L C R H P N T
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 2 magnesium ions for reverse transcriptase polymerase activity. {ECO:0000250}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 2 magnesium ions for ribonuclease H (RNase H) activity. Substrate-binding is a precondition for magnesium binding. {ECO:0000250}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Magnesium ions are required for integrase activity. Binds at least 1, maybe 2 magnesium ions. {ECO:0000250};
Active site	ACT_SITE 537 537 For protease activity; shared with dimeric partner. {ECO:0000255|PROSITE-ProRule:PRU10094}.
Pfam	PF00540 PF00607 PF00552 PF02022 PF00075 PF00665 PF00077 PF00078 PF06815 PF06817 PF00098
InterPro	IPR001969 IPR000721 IPR017856 IPR036862 IPR001037 IPR001584 IPR003308 IPR000071 IPR012344 IPR001995 IPR021109 IPR034170 IPR018061 IPR008916 IPR008919 IPR010999 IPR012337 IPR002156 IPR036397 IPR000477 IPR010659 IPR010661 IPR001878 IPR036875