Uniprot ID	P19110
Uniprot Name	POLG_JAEV5
Taxonomy ID	11074
Sequence	M T K K P G G P G K N R A I N M L K R G L P R V F P L V G V K R V V M S L L D G R G P V R F V L A L I T F F K F T A L A P T K A L L G R W K A V E K S V A M K H L T S F K R E L G T L I D A V N K R G R K Q N K R G G N E G S I M W L A S L A V V I A C A G A M K L S N F Q G K L L M T I N N T D I A D V I V I P T S K G E N R C W V R A I D V G Y M C E D T I T Y E C P K L T M G N D P E D V D C W C D N Q E V Y V Q Y G R C T R T R H S K R S R R S V S V Q T H G E S S L V N K K E A W L D S T K A T R Y L M K T E N W I I R N P G Y A F L A A V L G W M L G S N N G Q R V V F T I L L L L V A P A Y S F N C L G M G N R D F I E G A S G A T W V D L V L E G D S C L T I M A N D K P T L D V R M I N I E A S Q L A E V R S Y C Y H A S V T D I S T V A R C P T T G E A H N E K R A D S S Y V C K Q G F T D R G W G N G C G L F G K G S I D T C A K F S C T S K A I G R T I Q P E N I K Y E V G I F V H G T T T S E N H G N Y S A Q V G A S Q A A K F T V T P N A P S I T L K L G D Y G E V T L D C E P R S G L N T E A F Y V M T V G S K S F L V H R E W F H D L A L P W T S P S S T A W R N R E L L M E F E G A H A T K Q S V V A L G S Q E G G L H Q A L A G A I V V E Y S S S V K L T S G H L K C R L K M D K L A L K G T T Y G M C T E K F S F A K N P A D T G H G T V V I E L S Y S G S D G S C K I P I V S V A S L N D M T P V G R L V T V N P F V A T S S A N S K V L V E M E P P F G D S Y I V V G R G D K Q I N H H W H K A G S T L G K A F S T T L K G A Q R L A A L G D T A W D F G S I G G V F N S I G K A V H Q V F G G A F R T L F G G M S W I T Q G L M G A L L L W M G V N A R D R S I A L A F L A T G G V L V F L A T N V H A D T G C A I D I T R K E M R C G S G I F V H N D V E A W V D R Y K Y L P E T P R S L A K I V H K A H K E G V C G V R S V T R L E H Q M W E A V R D E L N V L L K E N A V D L S V V V N K P V G R Y R S A P K R L S M T Q E K F E M G W K A W G K S I L F A P E L A N S T F V V D G P E T K E C P D E H R A W N S M Q I E D F G F G I T S T R V W L K I R E E S T D E C D G A I I G T A V K G H V A V H S D L S Y W I E S R Y N D T W K L E R A V F G E V K S C T W P E T H T L W G D D V E E S E L I I P H T I A G P K S K H N R R E G Y K T Q N Q G P W D E N G I V L D F D Y C P G T K V T I T E D C G K R G P S V R T T T D S G K L I T D W C C R S C S L P P L R F R T E N G C W Y G M E I R P V R H D E T T L V R S Q V D A F N G E M V D P F Q L G L L V M F L A T Q E V L R K R W T A R L T I P A V L G A L L V L M L G G I T Y T D L A R Y V V L V A A A F A E A N S G G D V L H L A L I A V F K I Q P A F L V M N M L S T R W T N Q E N V V L V L G A A F F Q L A S V D L Q I G V H G I L N A A A I A W M I V R A I T F P T T S S V T M P V L A L L T P G M R A L Y L D T Y R I I L L V I G I C S L L H E R K K T M A K K K G A V L L G L A L T S T G W F S P T T I A A G L M V C N P N K K R G W P A T E F L S A V G L M F A I V G G L A E L D I E S M S I P F M L A G L M A V S Y V V S G K A T D M W L E R A A D I S W E M D A A I T G S S R R L D V K L D D D G D F H L I D D P G V P W K V W V L R M S C I G L A A L T P W A I V P A A F G Y W L T L K T T K R G G V F W D T P S P K P C S K G D T T T G V Y R I M A R G I L G T Y Q A G V G V M Y E N V F H T L W H T T R G A A I M S G E G K L T P Y W G S V R E D R I A Y G G P W R F D R K W N G T D D V Q V I V V E P G K A A V N I Q T K P G V F R T P F G E V G A V S L D Y P R G T S G S P I L D S N G D I I G L Y G N G V E L G D G S Y V S A I V Q G D R Q E E P V P E A Y T P N M L R K R Q M T V L D L H P G S G K T R K I L P Q I I K D A I Q Q R L R T A V L A P T R V V A A E M A E V L R G L P V R Y Q T S A V Q R E H Q G N E I V D V M C H A T L T H R L M S P N R V P N Y N L F V M D E A H F T D P A S I A A R G Y I A T K V E L G E A A A I F M T A T P P G T T D P F P D S N A P I H D L Q D E I P D R A W S S G Y E W I T E Y A G K T V W F V A S V K M G N E I A M C L Q R A G K K V I Q L N R K S Y D T E Y P K C K N G D W D F V I T T D I S E M G A N F G A S R V I D C R K S V K P T I L E E G E G R V I L G N P S P I T S A S A A Q R R G R V G R N P N Q V G D E Y H Y G G A T S E D D S N L A H W T E A K I M L D N I H M P N G L V A Q L Y G P E R E K A F T M D G E Y R L R G E E K K N F L E L L R T A D L P V W L A Y K V A S N G I Q Y T D R K W C F D G P R T N A I L E D N T E V E I V T R M G E R K I L K P R W L D A R V Y A D H Q A L K W F K D F A A G K R S A V S F I E V L G R M P E H F M G K T R E A L D T M Y L V A T A E K G G K A H R M A L E E L P D A L E T I T L I V A I T V M T G G F F L L M M Q R K G I G K M G L G A L V L T L A T F F L W A A E V P G T K I A G T L L I A L L L M V V L I P E P E K Q R S Q T D N Q L A V F L I C V L T V V G V V A A N E Y G M L E K T K A D L K S M F G G K T Q A S G L T G L P S M A L D L R P A T A W A L Y G G S T V V L T P L L K H L I T S E Y V T T S L A S I N S Q A G S L F V L P R G V P F T D L D L T V G L V F L G C W G Q I T L T T F L T A M V L A T L H Y G Y M L P G W Q A E A L R A A Q R R T A A G I M K N A V V D G M V A T D V P E L E R T T P L M Q K K V G Q V L L I G V S V A A F L V N P N V T T V R E A G V L V T A A T L T L W D N G A S A V W N S T T A T G L C H V M R G S Y L A G G S I A W T L I K N A D K P S L K R G R P G G R T L G E Q W K E K L N A M S R E E F F K Y R R E A I I E V D R T E A R R A R R E N N I V G G H P V S R G S A K L R W L V E K G F V S P I G K V I D L G C G R G G W S Y Y A A T L K K V Q E V R G Y T K G G A G H E E P M L M Q S Y G W N L V S L K S G V D V F Y K P S E P S D T L F C D I G E S S P S P E V E E Q R T L R V L E M T S D W L H R G P R E F C I K V L C P Y M P K V I E K M E V L Q R R F G G G L V R L P L S R N S N H E M Y W V S G A A G N V V H A V N M T S Q V L L G R M D R T V W R G P K Y E E D V N L G S G T R A V G K G E V H S N Q E K I K K R I Q K L K E E F A T T W H K D P E H P Y R T W T Y H G S Y E V K A T G S A S S L V N G V V K L M S K P W D A I A N V T T M A M T D T T P F G Q Q R V F K E K V D T K A P E P P A G A K E V L N E T T N W L W A H L S R E K R P R L C T K E E F I K K V N S N A A L G A V F A E Q N Q W S T A R E A V D D P R F W E M V D E E R E N H L R G E C H T C I Y N M M G K R E K K P G E F G K A K G S R A I W F M W L G A R Y L E F E A L G F L N E D H W L S R E N S G G G V E G S G V Q K L G Y I L R D I A G K Q G G K M Y A D D T A G W D T R I T R T D L E N E A K V L E L L D G E H R M L A R A I I E L T Y R H K V V K V M R P A A E G K T V M D V I S R E D Q R G S G Q V V T Y A L N T F T N I A V Q L V R L M E A E G V I G P Q H L E Q L P R K N K I A V R T W L F E N G E E R V T R M A I S G D D C V V K P L D D R F A T A L H F L N A M S K V R K D I Q E W K P S H G W H D W Q Q V P F C S N H F Q E I V M K D G R S I V V P C R G Q D E L I D R A R I S P G A G W N V K D T A C L A K A Y A Q M W L L L Y F H R R D L R L M A N A I C S A V P V D W V P T G R T S W S I H S K G E W M T T E D M L Q V W N R V W I E E N E W M M D K T P I T S W T D V P Y V G K R E D I W C G S L I G T R S R A T W A E N I Y A A I N Q V R A V I G K E N Y V D Y M T S L R R Y E D V L I Q E D R V I
Cofactor	COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For RNA-directed RNA polymerase NS5 activity; Mn(2+) is more effective than Mg(2+). {ECO:0000250|UniProtKB:P27395};
Active site	ACT_SITE 1555 1555 Charge relay system; for serine protease NS3 activity. {ECO:0000255|PROSITE-ProRule:PRU00860}.; ACT_SITE 1579 1579 Charge relay system; for serine protease NS3 activity. {ECO:0000255|PROSITE-ProRule:PRU00860}.; ACT_SITE 1639 1639 Charge relay system; for serine protease NS3 activity. {ECO:0000255|PROSITE-ProRule:PRU00860}.; ACT_SITE 2588 2588 For 2'-O-MTase activity. {ECO:0000250|UniProtKB:Q6YMS4}.; ACT_SITE 2673 2673 For 2'-O-MTase activity. {ECO:0000250|UniProtKB:Q6YMS4}.; ACT_SITE 2709 2709 For 2'-O-MTase activity. {ECO:0000250|UniProtKB:Q6YMS4}.; ACT_SITE 2745 2745 For 2'-O-MTase activity. {ECO:0000250|UniProtKB:Q6YMS4}.
Pfam	PF01003 PF07652 PF02832 PF00869 PF01004 PF00948 PF01005 PF01002 PF01350 PF01349 PF00972 PF01570 PF01728 PF00949
InterPro	IPR011492 IPR000069 IPR038302 IPR013755 IPR001122 IPR037172 IPR027287 IPR026470 IPR038345 IPR001157 IPR000752 IPR000487 IPR000404 IPR001528 IPR002535 IPR038688 IPR000336 IPR001850 IPR014412 IPR011998 IPR036253 IPR038055 IPR013756 IPR014001 IPR001650 IPR014756 IPR026490 IPR027417 IPR009003 IPR000208 IPR007094 IPR002877 IPR029063