Uniprot ID	P21726
Uniprot Name	TKTP_CUPNH
Taxonomy ID	381666
Sequence	M N A P E R I D P A A R C A N A L R F L A A D A V E L A R S G H P G A P M G M A E M A E V V W R R H L R H N P A N P A W P D R D R F V L S N G H A S M L Q Y A L L H L T G Y D L P M S Q L R Q F R Q L H A V T P G H P E V D V T P G V E T T T G P L G Q G L A N A V G M A L A E K L L A A T F N R P G F D I V D H H T Y V F L G D G C L M E G L S H E A C S L A G T L G L G K L I C L Y D D N G I S I D G E V A G W F A D D T P K R F A A Y G W H V I A D V D G H D A H A L D A A L H E A K A E R D R P T L I C C R T V I G K G A P A K A G G H D V H G A P L G A P E I A A M R T A L G W E A E P F T V P A D V A D A W D A R A Q G A A R E A E W E A R F V S Y C A A H P E L A E E F V R R A N G R L P E G F D A E L M A L L D A P S P L Q G K I A T R K A S Q L C L E A L T P A L P E L L G G S A D L T G S N L T N V K A S V W V N H A G H G N Y V S Y G V R E F G M A A V M N G I A L H G G L I P Y G G T F M T F S D Y S R N A I R M A A L M R L R V V H V L T H D S I G L G E D G P T H Q P V E H A A S L R L I P N N Q V W R P C D G A E T A Y A W L A A L Q R E N G P T C L V L S R Q A L M P F E R D A A Q R A D I A R G G Y V L R D V P A P R V V L I A T G S E V E I A A R A A L D L A D A G I A A R V V S M P C V E L F Y A Q D A A Y R D S V L P P G L P R I S V E A G A T W Y W R G V V G E Q G L A L G I D S F G E S A P A E A L Y Q H F G L T P A H V A A A A R V L L E D A
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000250}; Note=Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). {ECO:0000250}; COFACTOR: Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO:0000250};
Active site	ACT_SITE 417 417 Proton donor. {ECO:0000250}.
Pfam	PF02779 PF02780 PF00456
InterPro	IPR029061 IPR009014 IPR005475 IPR005478 IPR020826 IPR033248 IPR033247 IPR005474