Uniprot ID	P22079
Uniprot Name	PERL_HUMAN
Taxonomy ID	9606
Sequence	M R V L L H L P A L L A S L I L L Q A A A S T T R A Q T T R T S A I S D T V S Q A K V Q V N K A F L D S R T R L K T A M S S E T P T S R Q L S E Y L K H A K G R T R T A I R N G Q V W E E S L K R L R Q K A S L T N V T D P S L D L T S L S L E V G C G A P A P V V R C D P C S P Y R T I T G D C N N R R K P A L G A A N R A L A R W L P A E Y E D G L S L P F G W T P G K T R N G F P L P L A R E V S N K I V G Y L N E E G V L D Q N R S L L F M Q W G Q I V D H D L D F A P D T E L G S S E Y S K A Q C D E Y C I Q G D N C F P I M F P P N D P K A G T Q G K C M P F F R A G F V C P T P P Y K S L A R E Q I N A L T S F L D A S F V Y S S E P S L A S R L R N L S S P L G L M A V N Q E V S D H G L P Y L P Y D S K K P S P C E F I N T T A R V P C F L A G D S R A S E H I L L A T S H T L F L R E H N R L A R E L K R L N P Q W D G E K L Y Q E A R K I L G A F V Q I I T F R D Y L P I L L G D H M Q K W I P P Y Q G Y S E S V D P R I S N V F T F A F R F G H L E V P S S M F R L D E N Y Q P W G P E P E L P L H T L F F N T W R M V K D G G I D P L V R G L L A K K S K L M K Q N K M M T G E L R N K L F Q P T H R I H G F D L A A I N T Q R C R D H G Q P G Y N S W R A F C D L S Q P Q T L E E L N T V L K S K M L A K K L L G L Y G T P D N I D I W I G A I A E P L V E R G R V G P L L A C L L G K Q F Q Q I R D G D R F W W E N P G V F T N E Q K D S L Q K M S F S R L V C D N T R I T K V P R D P F W A N S Y P Y D F V D C S A I D K L D L S P W A S V K N
Cofactor	COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00298}; Note=Binds 1 Ca(2+) ion per heterodimer. {ECO:0000255|PROSITE-ProRule:PRU00298}; COFACTOR: Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence={ECO:0000255|PROSITE-ProRule:PRU00298}; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per heterodimer. {ECO:0000255|PROSITE-ProRule:PRU00298};
Active site	ACT_SITE 226 226 Proton acceptor. {ECO:0000255|PROSITE-ProRule:PRU00298}.
Pfam	PF03098
InterPro	IPR019791 IPR010255 IPR037120 IPR029587