Uniprot ID	P23254
Uniprot Name	TKT1_YEAST
Taxonomy ID	559292
Sequence	M T Q F T D I D K L A V S T I R I L A V D T V S K A N S G H P G A P L G M A P A A H V L W S Q M R M N P T N P D W I N R D R F V L S N G H A V A L L Y S M L H L T G Y D L S I E D L K Q F R Q L G S R T P G H P E F E L P G V E V T T G P L G Q G I S N A V G M A M A Q A N L A A T Y N K P G F T L S D N Y T Y V F L G D G C L Q E G I S S E A S S L A G H L K L G N L I A I Y D D N K I T I D G A T S I S F D E D V A K R Y E A Y G W E V L Y V E N G N E D L A G I A K A I A Q A K L S K D K P T L I K M T T T I G Y G S L H A G S H S V H G A P L K A D D V K Q L K S K F G F N P D K S F V V P Q E V Y D H Y Q K T I L K P G V E A N N K W N K L F S E Y Q K K F P E L G A E L A R R L S G Q L P A N W E S K L P T Y T A K D S A V A T R K L S E T V L E D V Y N Q L P E L I G G S A D L T P S N L T R W K E A L D F Q P P S S G S G N Y S G R Y I R Y G I R E H A M G A I M N G I S A F G A N Y K P Y G G T F L N F V S Y A A G A V R L S A L S G H P V I W V A T H D S I G V G E D G P T H Q P I E T L A H F R S L P N I Q V W R P A D G N E V S A A Y K N S L E S K H T P S I I A L S R Q N L P Q L E G S S I E S A S K G G Y V L Q D V A N P D I I L V A T G S E V S L S V E A A K T L A A K N I K A R V V S L P D F F T F D K Q P L E Y R L S V L P D N V P I M S V E V L A T T C W G K Y A H Q S F G I D R F G A S G K A P E V F K F F G F T P E G V A E R A Q K T I A F Y K G D K L I S P L K K A F
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:18186462}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:18186462}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:18186462}; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000269|PubMed:18186462}; Note=Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). {ECO:0000269|PubMed:18186462}; COFACTOR: Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000269|PubMed:18186462}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO:0000269|PubMed:18186462};
Active site	ACT_SITE 418 418 Proton donor. {ECO:0000305}.
Pfam	PF02779 PF02780 PF00456
InterPro	IPR029061 IPR009014 IPR005475 IPR005478 IPR020826 IPR033248 IPR033247 IPR005474