Uniprot ID	P26662
Uniprot Name	POLG_HCVJA
Taxonomy ID	11116
Sequence	M S T N P K P Q R K T K R N T N R R P Q D V K F P G G G Q I V G G V Y L L P R R G P R L G V R A T R K T S E R S Q P R G R R Q P I P K A R R P E G R T W A Q P G Y P W P L Y G N E G M G W A G W L L S P R G S R P S W G P T D P R R R S R N L G K V I D T L T C G F A D L M G Y I P L V G A P L G G A A R A L A H G V R V L E D G V N Y A T G N L P G C S F S I F L L A L L S C L T I P A S A Y E V R N V S G I Y H V T N D C S N S S I V Y E A A D M I M H T P G C V P C V R E S N F S R C W V A L T P T L A A R N S S I P T T T I R R H V D L L V G A A A L C S A M Y V G D L C G S V F L V S Q L F T F S P R R Y E T V Q D C N C S I Y P G H V S G H R M A W D M M M N W S P T T A L V V S Q L L R I P Q A V V D M V A G A H W G V L A G L A Y Y S M V G N W A K V L I V M L L F A G V D G H T H V T G G R V A S S T Q S L V S W L S Q G P S Q K I Q L V N T N G S W H I N R T A L N C N D S L Q T G F I A A L F Y A H R F N A S G C P E R M A S C R P I D E F A Q G W G P I T H D M P E S S D Q R P Y C W H Y A P R P C G I V P A S Q V C G P V Y C F T P S P V V V G T T D R F G A P T Y S W G E N E T D V L L L S N T R P P Q G N W F G C T W M N S T G F T K T C G G P P C N I G G V G N N T L V C P T D C F R K H P E A T Y T K C G S G P W L T P R C M V D Y P Y R L W H Y P C T V N F T V F K V R M Y V G G V E H R L N A A C N W T R G E R C D L E D R D R S E L S P L L L S T T E W Q I L P C S F T T L P A L S T G L I H L H R N I V D V Q Y L Y G I G S A V V S F A I K W E Y I L L L F L L L A D A R V C A C L W M M L L I A Q A E A T L E N L V V L N A A S V A G A H G L L S F L V F F C A A W Y I K G R L V P G A A Y A L Y G V W P L L L L L L A L P P R A Y A M D R E M A A S C G G A V F V G L V L L T L S P Y Y K V F L A R L I W W L Q Y F I T R A E A H L Q V W V P P L N V R G G R D A I I L L T C A V H P E L I F D I T K L L L A I L G P L M V L Q A G I T R V P Y F V R A Q G L I R A C M L V R K V A G G H Y V Q M A F M K L A A L T G T Y V Y D H L T P L R D W A H A G L R D L A V A V E P V V F S D M E T K L I T W G A D T A A C G D I I S G L P V S A R R G K E I L L G P A D S F G E Q G W R L L A P I T A Y S Q Q T R G L L G C I I T S L T G R D K N Q V D G E V Q V L S T A T Q S F L A T C V N G V C W T V Y H G A G S K T L A G P K G P I T Q M Y T N V D Q D L V G W P A P P G A R S M T P C T C G S S D L Y L V T R H A D V V P V R R R G D S R G S L L S P R P I S Y L K G S S G G P L L C P S G H V V G I F R A A V C T R G V A K A V D F I P V E S M E T T M R S P V F T D N S S P P A V P Q T F Q V A H L H A P T G S G K S T K V P A A Y A A Q G Y K V L V L N P S V A A T L G F G A Y M S K A H G I E P N I R T G V R T I T T G G P I T Y S T Y C K F L A D G G C S G G A Y D I I I C D E C H S T D S T T I L G I G T V L D Q A E T A G A R L V V L A T A T P P G S I T V P H P N I E E V A L S N T G E I P F Y G K A I P I E A I K G G R H L I F C H S K K K C D E L A A K L T G L G L N A V A Y Y R G L D V S V I P T S G D V V V V A T D A L M T G F T G D F D S V I D C N T C V T Q T V D F S L D P T F T I E T T T L P Q D A V S R A Q R R G R T G R G R S G I Y R F V T P G E R P S G M F D S S V L C E C Y D A G C A W Y E L T P A E T S V R L R A Y L N T P G L P V C Q D H L E F W E S V F T G L T H I D A H F L S Q T K Q A G D N L P Y L V A Y Q A T V C A R A Q A P P P S W D Q M W K C L I R L K P T L H G P T P L L Y R L G A V Q N E V T L T H P I T K Y I M A C M S A D L E V V T S T W V L V G G V L A A L A A Y C L T T G S V V I V G R I I L S G R P A V I P D R E V L Y Q E F D E M E E C A S H L P Y I E Q G M Q L A E Q F K Q K A L G L L Q T A T K Q A E A A A P V V E S K W R A L E V F W A K H M W N F I S G I Q Y L A G L S T L P G N P A I A S L M A F T A S I T S P L T T Q N T L L F N I L G G W V A A Q L A P P S A A S A F V G A G I A G A A V G S I G L G K V L V D I L A G Y G A G V A G A L V A F K V M S G E M P S T E D L V N L L P A I L S P G A L V V G V V C A A I L R R H V G P G E G A V Q W M N R L I A F A S R G N H V S P T H Y V P E S D A A A R V T Q I L S S L T I T Q L L K R L H Q W I N E D C S T P C S G S W L K D V W D W I C T V L S D F K T W L Q S K L L P R L P G L P F L S C Q R G Y K G V W R G D G I M Q T T C P C G A Q I T G H V K N G S M R I V G P K T C S N T W H G T F P I N A Y T T G P C T P S P A P N Y S R A L W R V A A E E Y V E V T R V G D F H Y V T G M T T D N V K C P C Q V P A P E F F T E V D G V R L H R Y A P V C K P L L R E E V V F Q V G L N Q Y L V G S Q L P C E P E P D V A V L T S M L T D P S H I T A E T A K R R L A R G S P P S L A S S S A S Q L S A P S L K A T C T T H H D S P D A D L I E A N L L W R Q E M G G N I T R V E S E N K V V I L D S F D P I R A V E D E R E I S V P A E I L R K P R K F P P A L P I W A R P D Y N P P L L E S W K D P D Y V P P V V H G C P L P S T K A P P I P P P R R K R T V V L T E S T V S S A L A E L A T K T F G S S G S S A V D S G T A T G P P D Q A S D D G D K G S D V E S Y S S M P P L E G E P G D P D L S D G S W S T V S G E A G E D V V C C S M S Y T W T G A L I T P C A A E E S K L P I N P L S N S L L R H H S M V Y S T T S R S A S L R Q K K V T F D R L Q V L D D H Y R D V L K E M K A K A S T V K A R L L S I E E A C K L T P P H S A K S K F G Y G A K D V R S L S S R A V N H I R S V W E D L L E D T E T P I D T T I M A K N E V F C V Q P E K G G R K P A R L I V F P D L G V R V C E K M A L Y D V V S T L P Q A V M G P S Y G F Q Y S P G Q R V E F L V N T W K S K K C P M G F S Y D T R C F D S T V T E N D I R T E E S I Y Q C C D L A P E A R Q A I R S L T E R L Y V G G P L T N S K G Q N C G Y R R C R A S G V L T T S C G N T L T C Y L K A T A A C R A A K L Q D C T M L V N G D D L V V I C E S A G T Q E D A A A L R A F T E A M T R Y S A P P G D P P Q P E Y D L E L I T S C S S N V S V A H D A S G K R V Y Y L T R D P T T P L A R A A W E T V R H T P V N S W L G N I I M Y A P T L W A R M I L M T H F F S I L L A Q E Q L E K A L D C Q I Y G A C Y S I E P L D L P Q I I E R L H G L S A F S L H S Y S P G E I N R V A S C L R K L G V P P L R V W R H R A R S V R A K L L S Q G G R A A T C G K Y L F N W A V K T K L K L T P I P A A S Q L D L S G W F V A G Y N G G D I Y H S L S R A R P R W F M L C L L L L S V G V G I Y L L P N R
Cofactor	COFACTOR: Serine protease NS3: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:9060645}; Note=Binds 1 zinc ion. {ECO:0000269|PubMed:9060645}; COFACTOR: Non-structural protein 5A: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion in the NS5A N-terminal domain. {ECO:0000250};
Active site	ACT_SITE 952 952 For protease NS2-3 activity; shared with dimeric partner. {ECO:0000255|PROSITE-ProRule:PRU01030}.; ACT_SITE 972 972 For protease NS2-3 activity; shared with dimeric partner. {ECO:0000255|PROSITE-ProRule:PRU01030}.; ACT_SITE 993 993 For protease NS2-3 activity; shared with dimeric partner. {ECO:0000255|PROSITE-ProRule:PRU01030}.; ACT_SITE 1083 1083 Charge relay system; for serine protease NS3 activity. {ECO:0000255|PROSITE-ProRule:PRU01166}.; ACT_SITE 1107 1107 Charge relay system; for serine protease NS3 activity. {ECO:0000255|PROSITE-ProRule:PRU01166}.; ACT_SITE 1165 1165 Charge relay system; for serine protease NS3 activity. {ECO:0000255|PROSITE-ProRule:PRU01166}.
Pfam	PF07652 PF01543 PF01542 PF01539 PF01560 PF01538 PF01006 PF01001 PF01506 PF08300 PF08301 PF12941 PF02907 PF00998
InterPro	IPR011492 IPR002521 IPR002522 IPR002519 IPR002531 IPR002518 IPR042205 IPR042209 IPR000745 IPR001490 IPR002868 IPR013193 IPR038568 IPR024350 IPR014001 IPR001650 IPR013192 IPR038170 IPR027417 IPR009003 IPR004109 IPR007094 IPR002166