Uniprot ID	P27302
Uniprot Name	TKT1_ECOLI
Taxonomy ID	83333
Sequence	M S S R K E L A N A I R A L S M D A V Q K A K S G H P G A P M G M A D I A E V L W R D F L K H N P Q N P S W A D R D R F V L S N G H G S M L I Y S L L H L T G Y D L P M E E L K N F R Q L H S K T P G H P E V G Y T A G V E T T T G P L G Q G I A N A V G M A I A E K T L A A Q F N R P G H D I V D H Y T Y A F M G D G C M M E G I S H E V C S L A G T L K L G K L I A F Y D D N G I S I D G H V E G W F T D D T A M R F E A Y G W H V I R D I D G H D A A S I K R A V E E A R A V T D K P S L L M C K T I I G F G S P N K A G T H D S H G A P L G D A E I A L T R E Q L G W K Y A P F E I P S E I Y A Q W D A K E A G Q A K E S A W N E K F A A Y A K A Y P Q E A A E F T R R M K G E M P S D F D A K A K E F I A K L Q A N P A K I A S R K A S Q N A I E A F G P L L P E F L G G S A D L A P S N L T L W S G S K A I N E D A A G N Y I H Y G V R E F G M T A I A N G I S L H G G F L P Y T S T F L M F V E Y A R N A V R M A A L M K Q R Q V M V Y T H D S I G L G E D G P T H Q P V E Q V A S L R V T P N M S T W R P C D Q V E S A V A W K Y G V E R Q D G P T A L I L S R Q N L A Q Q E R T E E Q L A N I A R G G Y V L K D C A G Q P E L I F I A T G S E V E L A V A A Y E K L T A E G V K A R V V S M P S T D A F D K Q D A A Y R E S V L P K A V T A R V A V E A G I A D Y W Y K Y V G L N G A I V G M T T F G E S A P A E L L F E E F G F T V D N V V A K A K E L L
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:7607225}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:7607225}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:7607225}; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000269|PubMed:7607225}; Note=Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). {ECO:0000269|PubMed:7607225}; COFACTOR: Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000269|PubMed:7607225}; Note=Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor. {ECO:0000269|PubMed:17914867};
Active site	ACT_SITE 411 411 Proton donor. {ECO:0000305}.
Pfam	PF02779 PF02780 PF00456
InterPro	IPR029061 IPR009014 IPR005475 IPR005478 IPR020826 IPR033248 IPR033247 IPR005474