Uniprot ID	P27570
Uniprot Name	TOP2_CRIFA
Taxonomy ID	5656
Sequence	M T D A S K Y Q K L T P I D H V L L R P E M Y V G S I E T Q S I P M F V F D P A K G K M V W E S M Q V N Q G L L K I V D E I L L N A A D N I N N S V R G A R M T Y I S I K I S D S G E I M V E N D G A G L P I V K S K E H K M Y I P E M V F G H L L T S S N Y N N D A S S T T A G R H G Y G A K L T N I L S T K F S V V C R T A G R E F H M S W T D H M R M A T T P R V S N V D P K E K N V T R V T F M P D Y A H F G F P T A A I S L D M K R V L H K R I M D L A A M F S K I E V R L N N V P F G F Q T F N D Y A R L Y S L P G A D G A M P P E P F V H T G P N G S I A F V P Q L T Q S P K R I V G V V N G V V T Y N G G T H C T S A M E I L E T G L D S L S R S L K K D G K V I D T N R V A R H F T V L V F L I Q S Q P K F D S Q S K A R L V S T V T M P R V P R T A L D Q Y L A A M P F L E A H M N S M D D Q L A A E L N K E I G T G K R L S S R S L I S S I T K L V D A T S S R S D G K N I R T L I V T E G D S A K A L A L N S L S S E Q K K F C G V F P L R G K L L N V R N K N L K R L K T C K E L Q D L F L A L G L E L G K T Y K S P A E L R Y Q R L L V M T D Q D A D G S H I K G L V I N A F E S L W P S L L Q H N P G Y I S L F S T P I V K I K V N G K A K E V V A F H S F R D F H R W Q R A N P N A R Y S A K Y Y K G L G T S T T A E G K E Y F A D M E R N V M R L V V E P K D H R L L D S V F D S A E V E W R K E W M S K A N A F Q G E V D I D R S K K L L T I G D F V H K E M V H F A L V G N A R A I P H C V D G L K P S Q R K I L W A M L K R H S S E A A K V A Q L S G Y I S E V S S F H H G E A S L Q E T I V K M A Q N F T G G N N I N L L V P E G Q F G S R Q Q L G N D H A A P R Y I F T K L S R F A R L L F P E D D D P L L D Y I D E E G T M V E P N H Y V P I L P L L L C N G A V G I G F G F A T N I P S F H P L D V S A A V R A M I N G E S A K Q V V R N L V P W A V G F Q G T V R R G P E K E Y I A V G K Y T A H R N G R L H V S E L P W M T S I E A F R S H I S S L A S S D V V Q R I A D Y S G A N H I D I D L I V R E G S M T T W A E C E T D L A L S Q R I Y I N G T V F S P D G T L S P I D A D L S P V L Q W H Y D R R L D L Y K R R R T R Q I G L L E M D L A R L Q S T R K F V E H F R Q G H I D F L A A T D D T L T K T C V K L G L V R V D D G Y D Y I L K K P I T F Y T K T S T E K L Q A D I K K T Q D S I A V L K Q T T P V K M W L T D L D K F D K T F Q E Y E R V L I H S I Q K E Q R P A S I T G G E E V P A L R Q P P L M L E A P A K G A A S S S Y R V H I C R Y E E P P A S K R K P E D T Y G G A L S S G G S T R N V G K R L T G A R G A K K K K V V R R T R T K M S L G T R V A E F A G A Q L G R L L P Q L P R L L F
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 775 775 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250|UniProtKB:P06786}.
Pfam	PF00204 PF00521 PF02518 PF01751 PF16898
InterPro	IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013757 IPR013759 IPR013506 IPR018522 IPR031660 IPR006171