Uniprot ID	P27708
Uniprot Name	PYR1_HUMAN
Taxonomy ID	9606
Sequence	M A A L V L E D G S V L R G Q P F G A A V S T A G E V V F Q T G M V G Y P E A L T D P S Y K A Q I L V L T Y P L I G N Y G I P P D E M D E F G L C K W F E S S G I H V A A L V V G E C C P T P S H W S A T R T L H E W L Q Q H G I P G L Q G V D T R E L T K K L R E Q G S L L G K L V Q N G T E P S S L P F L D P N A R P L V P E V S I K T P R V F N T G G A P R I L A L D C G L K Y N Q I R C L C Q R G A E V T V V P W D H A L D S Q E Y E G L F L S N G P G D P A S Y P S V V S T L S R V L S E P N P R P V F G I C L G H Q L L A L A I G A K T Y K M R Y G N R G H N Q P C L L V G S G R C F L T S Q N H G F A V E T D S L P A D W A P L F T N A N D G S N E G I V H N S L P F F S V Q F H P E H Q A G P S D M E L L F D I F L E T V K E A T A G N P G G Q T V R E R L T E R L C P P G I P T P G S G L P P P R K V L I L G S G G L S I G Q A G E F D Y S G S Q A I K A L K E E N I Q T L L I N P N I A T V Q T S Q G L A D K V Y F L P I T P H Y V T Q V I R N E R P D G V L L T F G G Q T A L N C G V E L T K A G V L A R Y G V R V L G T P V E T I E L T E D R R A F A A R M A E I G E H V A P S E A A N S L E Q A Q A A A E R L G Y P V L V R A A F A L G G L G S G F A S N R E E L S A L V A P A F A H T S Q V L V D K S L K G W K E I E Y E V V R D A Y G N C V T V C N M E N L D P L G I H T G E S I V V A P S Q T L N D R E Y Q L L R Q T A I K V T Q H L G I V G E C N V Q Y A L N P E S E Q Y Y I I E V N A R L S R S S A L A S K A T G Y P L A Y V A A K L A L G I P L P E L R N S V T G G T A A F E P S V D Y C V V K I P R W D L S K F L R V S T K I G S C M K S V G E V M G I G R S F E E A F Q K A L R M V D E N C V G F D H T V K P V S D M E L E T P T D K R I F V V A A A L W A G Y S V D R L Y E L T R I D R W F L H R M K R I I A H A Q L L E Q H R G Q P L P P D L L Q Q A K C L G F S D K Q I A L A V L S T E L A V R K L R Q E L G I C P A V K Q I D T V A A E W P A Q T N Y L Y L T Y W G T T H D L T F R T P H V L V L G S G V Y R I G S S V E F D W C A V G C I Q Q L R K M G Y K T I M V N Y N P E T V S T D Y D M C D R L Y F D E I S F E V V M D I Y E L E N P E G V I L S M G G Q L P N N M A M A L H R Q Q C R V L G T S P E A I D S A E N R F K F S R L L D T I G I S Q P Q W R E L S D L E S A R Q F C Q T V G Y P C V V R P S Y V L S G A A M N V A Y T D G D L E R F L S S A A A V S K E H P V V I S K F I Q E A K E I D V D A V A S D G V V A A I A I S E H V E N A G V H S G D A T L V T P P Q D I T A K T L E R I K A I V H A V G Q E L Q V T G P F N L Q L I A K D D Q L K V I E C N V R V S R S F P F V S K T L G V D L V A L A T R V I M G E E V E P V G L M T G S G V V G V K V P Q F S F S R L A G A D V V L G V E M T S T G E V A G F G E S R C E A Y L K A M L S T G F K I P K K N I L L T I G S Y K N K S E L L P T V R L L E S L G Y S L Y A S L G T A D F Y T E H G V K V T A V D W H F E E A V D G E C P P Q R S I L E Q L A E K N F E L V I N L S M R G A G G R R L S S F V T K G Y R T R R L A A D F S V P L I I D I K C T K L F V E A L G Q I G P A P P L K V H V D C M T S Q K L V R L P G L I D V H V H L R E P G G T H K E D F A S G T A A A L A G G I T M V C A M P N T R P P I I D A P A L A L A Q K L A E A G A R C D F A L F L G A S S E N A G T L G T V A G S A A G L K L Y L N E T F S E L R L D S V V Q W M E H F E T W P S H L P I V A H A E Q Q T V A A V L M V A Q L T Q R S V H I C H V A R K E E I L L I K A A K A R G L P V T C E V A P H H L F L S H D D L E R L G P G K G E V R P E L G S R Q D V E A L W E N M A V I D C F A S D H A P H T L E E K C G S R P P P G F P G L E T M L P L L L T A V S E G R L S L D D L L Q R L H H N P R R I F H L P P Q E D T Y V E V D L E H E W T I P S H M P F S K A H W T P F E G Q K V K G T V R R V V L R G E V A Y I D G Q V L V P P G Y G Q D V R K W P Q G A V P Q L P P S A P A T S E M T T T P E R P R R G I P G L P D G R F H L P P R I H R A S D P G L P A E E P K E K S S R K V A E P E L M G T P D G T C Y P P P P V P R Q A S P Q N L G T P G L L H P Q T S P L L H S L V G Q H I L S V Q Q F T K D Q M S H L F N V A H T L R M M V Q K E R S L D I L K G K V M A S M F Y E V S T R T S S S F A A A M A R L G G A V L S F S E A T S S V Q K G E S L A D S V Q T M S C Y A D V V V L R H P Q P G A V E L A A K H C R R P V I N A G D G V G E H P T Q A L L D I F T I R E E L G T V N G M T I T M V G D L K H G R T V H S L A C L L T Q Y R V S L R Y V A P P S L R M P P T V R A F V A S R G T K Q E E F E S I E E A L P D T D V L Y M T R I Q K E R F G S T Q E Y E A C F G Q F I L T P H I M T R A K K K M V V M H P M P R V N E I S V E V D S D P R A A Y F R Q A E N G M Y I R M A L L A T V L G R F
Cofactor	COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:24332717, ECO:0000269|PubMed:7766613}; Note=Binds 3 Zn(2+) ions per subunit (for dihydroorotase activity). {ECO:0000269|PubMed:24332717, ECO:0000269|PubMed:7766613}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00409}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00409}; Note=Binds 4 magnesium or manganese ions per subunit. {ECO:0000255|PROSITE-ProRule:PRU00409};
Active site	ACT_SITE 252 252 Nucleophile; for GATase activity. {ECO:0000255|PROSITE-ProRule:PRU00605}.; ACT_SITE 336 336 For GATase activity. {ECO:0000255|PROSITE-ProRule:PRU00605}.; ACT_SITE 338 338 For GATase activity. {ECO:0000255|PROSITE-ProRule:PRU00605}.
Pfam	PF01979 PF02786 PF02787 PF00988 PF00117 PF02142 PF00185 PF02729
InterPro	IPR006680 IPR006132 IPR006130 IPR036901 IPR002082 IPR006131 IPR011761 IPR013815 IPR006275 IPR005480 IPR036897 IPR006274 IPR002474 IPR036480 IPR005479 IPR005483 IPR029062 IPR035686 IPR002195 IPR017926 IPR011059 IPR032466 IPR011607 IPR036914 IPR016185