Uniprot ID	P27815
Uniprot Name	PDE4A_HUMAN
Taxonomy ID	9606
Sequence	M E P P T V P S E R S L S L S L P G P R E G Q A T L K P P P Q H L W R Q P R T P I R I Q Q R G Y S D S A E R A E R E R Q P H R P I E R A D A M D T S D R P G L R T T R M S W P S S F H G T G T G S G G A G G G S S R R F E A E N G P T P S P G R S P L D S Q A S P G L V L H A G A A T S Q R R E S F L Y R S D S D Y D M S P K T M S R N S S V T S E A H A E D L I V T P F A Q V L A S L R S V R S N F S L L T N V P V P S N K R S P L G G P T P V C K A T L S E E T C Q Q L A R E T L E E L D W C L E Q L E T M Q T Y R S V S E M A S H K F K R M L N R E L T H L S E M S R S G N Q V S E Y I S T T F L D K Q N E V E I P S P T M K E R E K Q Q A P R P R P S Q P P P P P V P H L Q P M S Q I T G L K K L M H S N S L N N S N I P R F G V K T D Q E E L L A Q E L E N L N K W G L N I F C V S D Y A G G R S L T C I M Y M I F Q E R D L L K K F R I P V D T M V T Y M L T L E D H Y H A D V A Y H N S L H A A D V L Q S T H V L L A T P A L D A V F T D L E I L A A L F A A A I H D V D H P G V S N Q F L I N T N S E L A L M Y N D E S V L E N H H L A V G F K L L Q E D N C D I F Q N L S K R Q R Q S L R K M V I D M V L A T D M S K H M T L L A D L K T M V E T K K V T S S G V L L L D N Y S D R I Q V L R N M V H C A D L S N P T K P L E L Y R Q W T D R I M A E F F Q Q G D R E R E R G M E I S P M C D K H T A S V E K S Q V G F I D Y I V H P L W E T W A D L V H P D A Q E I L D T L E D N R D W Y Y S A I R Q S P S P P P E E E S R G P G H P P L P D K F Q F E L T L E E E E E E E I S M A Q I P C T A Q E A L T A Q G L S G V E E A L D A T I A W E A S P A Q E S L E V M A Q E A S L E A E L E A V Y L T Q Q A Q S T G S A P V A P D E F S S R E E F V V A V S H S S P S A L A L Q S P L L P A W R T L S V S E H A P G L P G L P S T A A E V E A Q R E H Q A A K R A C S A C A G T F G E D T S A L P A P G G G G S G G D P T
Cofactor	COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence={ECO:0000269|PubMed:17727341}; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. {ECO:0000269|PubMed:17727341};
Active site	ACT_SITE 433 433 Proton donor. {ECO:0000250}.
Pfam	PF18100 PF00233
InterPro	IPR003607 IPR040844 IPR023088 IPR002073 IPR036971 IPR023174