Uniprot ID	P29401
Uniprot Name	TKT_HUMAN
Taxonomy ID	9606
Sequence	M E S Y H K P D Q Q K L Q A L K D T A N R L R I S S I Q A T T A A G S G H P T S C C S A A E I M A V L F F H T M R Y K S Q D P R N P H N D R F V L S K G H A A P I L Y A V W A E A G F L A E A E L L N L R K I S S D L D G H P V P K Q A F T D V A T G S L G Q G L G A A C G M A Y T G K Y F D K A S Y R V Y C L L G D G E L S E G S V W E A M A F A S I Y K L D N L V A I L D I N R L G Q S D P A P L Q H Q M D I Y Q K R C E A F G W H A I I V D G H S V E E L C K A F G Q A K H Q P T A I I A K T F K G R G I T G V E D K E S W H G K P L P K N M A E Q I I Q E I Y S Q I Q S K K K I L A T P P Q E D A P S V D I A N I R M P S L P S Y K V G D K I A T R K A Y G Q A L A K L G H A S D R I I A L D G D T K N S T F S E I F K K E H P D R F I E C Y I A E Q N M V S I A V G C A T R N R T V P F C S T F A A F F T R A F D Q I R M A A I S E S N I N L C G S H C G V S I G E D G P S Q M A L E D L A M F R S V P T S T V F Y P S D G V A T E K A V E L A A N T K G I C F I R T S R P E N A I I Y N N N E D F Q V G Q A K V V L K S K D D Q V T V I G A G V T L H E A L A A A E L L K K E K I N I R V L D P F T I K P L D R K L I L D S A R A T K G R I L T V E D H Y Y E G G I G E A V S S A V V G E P G I T V T H L A V N R V P R S G K P A E L L K M F G I D R D A I A Q A V R G L I T K A
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:3248678}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:3248678}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:3248678}; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000269|PubMed:3248678}; Note=Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). {ECO:0000269|PubMed:3248678}; COFACTOR: Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000269|PubMed:3248678}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO:0000269|PubMed:3248678};
Active site	ACT_SITE 366 366 Proton donor. {ECO:0000250}.
Pfam	PF02779 PF02780 PF00456
InterPro	IPR029061 IPR009014 IPR005475 IPR020826 IPR033248 IPR005474