Uniprot ID	P30182
Uniprot Name	TOP2_ARATH
Taxonomy ID	3702
Sequence	M A T K L P L Q N S N A A N V A K A P A K S R A A A G G K T I E E M Y Q K K S Q L E H I L L R P D T Y I G S I E K H T Q T L W V Y E K D E M V Q R P V T Y V P G L Y K I F D E I L V N A A D N K Q R D A K M D S V Q V V I D V E Q N L I S V C N S G A G V P V E I H Q E E G I Y V P E M I F G H L L T S S N Y D D N V K K T T G G R N G Y G A K L T N I F S T E F I I E T A D G K R L K K Y K Q V F E N N M G K K S E P V I T K C N K S E N W T K V T F K P D L K K F N M T E L E D D V V A L M S K R V F D I A G C L G K S V K V E L N G K Q I P V K S F T D Y V D L Y L S A A N K S R T E D P L P R L T E K V N D R W E V C V S L S E G Q F Q Q V S F V N S I A T I K G G T H V D Y V T S Q I T N H I V A A V N K K N K N A N V K A H N V K N H L W V F V N A L I D N P A F D S Q T K E T L T L R Q S S F G S K C E L S E D F L K K V G K S G V V E N L L S W A D F K Q N K D L K K S D G A K T G R V L V E K L D D A A E A G G K N S R L C T L I L T E G D S A K S L A L A G R S V L G N N Y C G V F P L R G K L L N V R E A S T T Q I T N N K E I E N L K K I L G L K Q N M K Y E N V N S L R Y G Q M M I M T D Q D H D G S H I K G L L I N F I H S F W P S L L Q V P S F L V E F I T P I V K A T R K G T K K V L S F Y S M P E Y E E W K E S L K G N A T G W D I K Y Y K G L G T S T A E E G K E Y F S N L G L H K K D F V W E D E Q D G E A I E L A F S K K K I E A R K N W L S S Y V P G N H L D Q R Q P K V T Y S D F V N K E L I L F S M A D L Q R S I P S M V D G L K P G Q R K I L F V A F K K I A R K E M K V A Q L V G Y V S L L S A Y H H G E Q S L A S A I I G M A Q D Y V G S N N I N L L L P N G Q F G T R T S G G K D S A S A R Y I F T K L S P V T R I L F P K D D D L L L D Y L N E D G Q R I E P T W Y M P I I P T V L V N G A E G I G T G W S T F I P N Y N P R E I V A N V R R L L N G E S M V P M D P W Y R G F K G T I E K T A S K E G G C T Y T I T G L Y E E V D E T T I R I T E L P I R R W N D D Y K N F L Q S L K T D N G A P F F Q D V K A Y N D E K S V D F D L I L S E E N M L A A R Q E G F L K K F K L T T T I A T S N M H L F D K K G V I K K Y V T P E Q I L E E F F D L R F E Y Y E K R K E T V V K N M E I E L L K L E N K A R F I L A V L S G E I I V N K R K K A D I V E D L R Q K G F T P F P R K A E S V E A A I A G A V D D D A A E E P E E I L V D P E S S S S Y I P G S E Y D Y L L A M A I A S L T I E K V E E L L A D R D K M I I A V A D M K K T T P K S L W L S D L E S L D K E L E K L D L K D A Q V Q Q A I E A A Q K K I R A K S G A A V K V K R Q A P K K P A P K K T T K K A S E S E T T E A S Y S A M D T D N N V A E V V K P K A R Q G A K K K A S E S E T T E A S H S A M D T D N N V A E V V K P K G R Q G A K K K A P A A A K E V E E D E M L D L A Q R L A Q Y N F G S A P A D S S K T A E T S K A I A V D D D D D D V V V E V A P V K K G G R K P A A T K A A K P P A A P R K R G K Q T V A S T E V L A I G V S P E K K V R K M R S S P F N K K S S S V M S R L A D N K E E E S S E N V A G N S S S E K S G G D V S A I S R P Q R A N R R K M T Y V L S D S E S E S A N D S E F D D I E D D E D D E
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 794 794 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250|UniProtKB:P06786}.
Pfam	PF00204 PF00521 PF02518 PF01751 PF16898
InterPro	IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013757 IPR013759 IPR013506 IPR018522 IPR031660 IPR006171 IPR034157