Uniprot ID	P30190
Uniprot Name	TOP2_TRYCR
Taxonomy ID	5693
Sequence	M A E A S K Y K K L T P I D H V L I R P E M Y V G S V D T S S S S M F V F D H E K G R M V W E S L K V N H G L L K I V D E I L L N A S D N I A N K G G R M T Y I R V H I T E A G E I T I E N D G A G I P I V R S K E H K L Y I P E M V F G H L L T S S N Y D D T S Q N A V A G R H G Y G A K L T N I L S H R F S V C C R T K G K E F H M S W H D H M R R A T A P R V S N V D P K E K N L T R V K F L P D Y E R F G L D A N K I S H D M K R V L H K R I M D L A A M F P S I E I S L N G V P F A F K S F A D Y A M L Y S S P S S S G E M P P A P F V Y E S R N G A I A F I P S L T A G T R R I F G V V N G V V T H N G G T H C N A A Q E V L Q S S L E S V E K A L K K D N K V I D T N R V L R H F M I L V F L V Q V Q P K F D S Q N K A R L V S V P T M P R V P R Q E L M D F L L R M P F L E A H V N T V T G Q L A D E L N K E M G A G R R M S S K S L I S S I T K L V D A T T T R R D P R F V R T L I V T E G D S A K A L A Q N S L S S D Q K R Y T G V F P L R G K L L N V R N K N L K R L K N C K E L Q E L F C A L G L E L G K I Y K D A E E L R Y Q R L L V M T D Q D A D G S H I K G L V I N A F E A L W P S L L N R N P G F I S I F S T P I V K V R L R D K S T H S F F S L K E F H K W Q K T H G N V S Y T A K Y Y K A L G T S T T A E G K E Y F K D M D K H T M R L V V E R N D H K L L D S V F D S Q E V E W R K D W M T K A N A Y T G E V D I D R S K K T L T V P D F V H K E M V H F A L A G N A R A L A H A V D G L K P S Q R K I L W A I M R R S G N E S A K V A Q L S G Y I S E V S A F H H G E M S L Q E T I I K M A Q N F T G G N N I N L L I P E G Q F G S R Q Q L G N D H A A A R Y I F T K L S S L A R I L F P S E D E P L L D Y V T E E G Q Q V E P N H Y V P I L P L L L C N G S V G I G F G F A S N I P P F H P L D V S A A V R S M I N G E A A K V V V R R L V P W A V G Y Q G E V R R G P E G E F I A A G S Y Q Y Y V D G R V H V T E I P W T L S I E A F R D H I S V L A S K D V V Q R I A D Y S G A N H V D I D L E L T N G A M T T Y A E C E S E L S L T Q R I Y I N G T V F S P T G V L T P L E G D L A P V L Q W H Y D R R L D L Y K K R R Q R N L G L L E A E L A R E K S T L K F V T H F R E G K I D I V N A T D D S L A K T C S K L G M V R V D D S Y D Y V L R K P I T F Y T K T S L E N L N R K I S E T E K R I D K L K K T A P V Q M W L D E L D R F D R A F E E H E N T A V A T I L K E R R V N P P T G D V S R N L Q Q P R L E L E E V K V S S S G G K S V P M R V R V R K Y V P P P P S K R P H V G Q S V G G G G G G G S V R S S A A A V V A H V K A E K K A A R A R S M Q K M L L D V V A R Q V A R V L P R L P W F L F
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 771 771 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250|UniProtKB:P06786}.
Pfam	PF00204 PF00521 PF02518 PF01751 PF16898
InterPro	IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013757 IPR013759 IPR013506 IPR018522 IPR031660 IPR006171