Uniprot ID	P33315
Uniprot Name	TKT2_YEAST
Taxonomy ID	559292
Sequence	M A Q F S D I D K L A V S T L R L L S V D Q V E S A Q S G H P G A P L G L A P V A H V I F K Q L R C N P N N E H W I N R D R F V L S N G H S C A L L Y S M L H L L G Y D Y S I E D L R Q F R Q V N S R T P G H P E F H S A G V E I T S G P L G Q G I S N A V G M A I A Q A N F A A T Y N E D G F P I S D S Y T F A I V G D G C L Q E G V S S E T S S L A G H L Q L G N L I T F Y D S N S I S I D G K T S Y S F D E D V L K R Y E A Y G W E V M E V D K G D D D M E S I S S A L E K A K L S K D K P T I I K V T T T I G F G S L Q Q G T A G V H G S A L K A D D V K Q L K K R W G F D P N K S F V V P Q E V Y D Y Y K K T V V E P G Q K L N E E W D R M F E E Y K T K F P E K G K E L Q R R L N G E L P E G W E K H L P K F T P D D D A L A T R K T S Q Q V L T N M V Q V L P E L I G G S A D L T P S N L T R W E G A V D F Q P P I T Q L G N Y A G R Y I R Y G V R E H G M G A I M N G I S A F G A N Y K P Y G G T F L N F V S Y A A G A V R L A A L S G N P V I W V A T H D S I G L G E D G P T H Q P I E T L A H L R A I P N M H V W R P A D G N E T S A A Y Y S A I K S G R T P S V V A L S R Q N L P Q L E H S S F E K A L K G G Y V I H D V E N P D I I L V S T G S E V S I S I D A A K K L Y D T K K I K A R V V S L P D F Y T F D R Q S E E Y R F S V L P D G V P I M S F E V L A T S S W G K Y A H Q S F G L D E F G R S G K G P E I Y K L F D F T A D G V A S R A E K T I N Y Y K G K Q L L S P M G R A F
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000250}; Note=Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). {ECO:0000250}; COFACTOR: Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO:0000250};
Active site	ACT_SITE 418 418 Proton donor. {ECO:0000250}.
Pfam	PF02779 PF02780 PF00456
InterPro	IPR029061 IPR009014 IPR005475 IPR005478 IPR020826 IPR033248 IPR033247 IPR005474