Uniprot ID	P33570
Uniprot Name	TKT2_ECOLI
Taxonomy ID	83333
Sequence	M S R K D L A N A I R A L S M D A V Q K A N S G H P G A P M G M A D I A E V L W N D F L K H N P T D P T W Y D R D R F I L S N G H A S M L L Y S L L H L T G Y D L P L E E L K N F R Q L H S K T P G H P E I G Y T P G V E T T T G P L G Q G L A N A V G L A I A E R T L A A Q F N Q P D H E I V D H F T Y V F M G D G C L M E G I S H E V C S L A G T L G L G K L I G F Y D H N G I S I D G E T E G W F T D D T A K R F E A Y H W H V I H E I D G H D P Q A V K E A I L E A Q S V K D K P S L I I C R T V I G F G S P N K A G K E E A H G A P L G E E E V A L A R Q K L G W H H P P F E I P K E I Y H A W D A R E K G E K A Q Q S W N E K F A A Y K K A H P Q L A E E F T R R M S G G L P K D W E K T T Q K Y I N E L Q A N P A K I A T R K A S Q N T L N A Y G P M L P E L L G G S A D L A P S N L T I W K G S V S L K E D P A G N Y I H Y G V R E F G M T A I A N G I A H H G G F V P Y T A T F L M F V E Y A R N A A R M A A L M K A R Q I M V Y T H D S I G L G E D G P T H Q A V E Q L A S L R L T P N F S T W R P C D Q V E A A V G W K L A V E R H N G P T A L I L S R Q N L A Q V E R T P D Q V K E I A R G G Y V L K D S G G K P D I I L I A T G S E M E I T L Q A A E K L A G E G R N V R V V S L P S T D I F D A Q D E E Y R E S V L P S N V A A R V A V E A G I A D Y W Y K Y V G L K G A I V G M T G Y G E S A P A D K L F P F F G F T A E N I V A K A H K V L G V K G A
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000250}; Note=Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). {ECO:0000250}; COFACTOR: Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO:0000250};
Active site	ACT_SITE 410 410 Proton donor. {ECO:0000250}.
Pfam	PF02779 PF02780 PF00456
InterPro	IPR029061 IPR009014 IPR005475 IPR005478 IPR020826 IPR033248 IPR033247 IPR005474