Uniprot ID	P34534
Uniprot Name	TOP2M_CAEEL
Taxonomy ID	6239
Sequence	M H R L R V L R H L K F C I S T S H R T T V V L K N T R S F C N N I P S T S F A S E A A A K Y E K K S P T E H V L L R P D T Y I G G V A M R E D Q I I W L R D S E N R K M I A K E V T Y P P G L L K I F D E I L V N A A D N K A R D S S M N R L E V W L D R E T A R I S V W N N G S G L P V E I H P T E G I Y V P T L V F G N L F T S S N Y D D S E I K T V G G R N G Y G A K L C N I F S K E F I V E T V D T R I K R R F R Q K W Y D N M K K C N E A E V V E I L D E T V K D Y T K V E F V P D L E R F Q I D K L S D D V I D L I G R R V F E V A A T L P R D V D V Y L N G Q K C D V D G F E D Y V K M F N D S S S L L F L H P T P R W H V G V A K R N N F F G E S H V V L P K I V S F V N N I N T E K G G S H V D Y V M D K I V N I I K P I V D S K L G D P T K S V K P A V I K N N L S I F I N C L I E N P S F E S Q T K E T L T T K A K N F G S I F E C D A K K T A E W A E Q S G L I E D I V E E V L N M K K K K L P G K R V S V S S V R D I V K L E D A E W A G I T G T A E K C T L I L T E G D S A K A L A L A G L E V L G R E T Y G V F P L K G K L L N V S N L D D A R A S K N E E I S N L L R I L G L K F E D S N S I T R E S L R Y G R L L I L A D Q D E D G S H I K G L I V N F I H K F W P S L V H T D G F I Q S F R T P L L K A K K G D K V R S F F S M N E Y R K W A D V E E G G K W K I K Y Y K G L G T S T S N E A R E Y F S D L D H H T V N F K Y T G T T D D D A I R M A F D R D K S D E R K E W I R R S E N E I T N E D D G K T E I S Y Q E F V D G Q L M Q F G M V D L K R S I P S L I D G L K P S Q R K I L W T L L N N M D E S T E I K V S Q L A G A V A H R Q S Y H H G E E S L V R T I I R M G Q T F C G S S N L P L L Q P I G Q F G T R H E G G N D A A S A R Y I F T A L A P T T R L L F P Q A D D D L L Q K N V E E G M V V E P T W L C P I V P L I L I N G T E G I G T G W S T K I A N R N P I D I I D M I R R K I D S I S T E Y E I P P F Y E E F R G K L E V V T P T K F I S S G K I Q L I R P E R K N A S T F S I E I V E L P I G I W T S K Y K E K L S K I V E T L P V L E F S E R H T E K R V H F R I T L D R K K S S R F L Q K S N S D L L N Y F K L R T S L T E N R V L F D R N G E L K E F G N I S E I A A E F F E V R R D L Y E K R L K I Q K E E C E A K L I Y V E N Q L N F I E M V T N G T I E I R S M G R N Q L E E K L Q E M G F R V D P M A T I A K N S K K A N Y G Y L L E M P V S R L T S D E M K R L E E R K S R R R T E L E A A E S A D W K S V W R S E L D K L A E A V G N N R K S
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 813 813 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250}.
Pfam	PF00204 PF00521 PF02518 PF01751 PF16898
InterPro	IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013757 IPR013759 IPR013506 IPR018522 IPR031660 IPR006171 IPR034157