Uniprot ID	P36328
Uniprot Name	POLN_EEVVP
Taxonomy ID	36385
Sequence	M E K V H V D I E E D S P F L R A L Q R S F P Q F E V E A K Q V T D N D H A N A R A F S H L A S K L I E T E V D P S D T I L D I G S A P A R R M Y S K H K Y H C I C P M R C A E D P D R L Y K Y A T K L K K N C K E I T D K E L D K K M K E L A A V M S D P D L E T E T M C L H D D E S C R Y E G Q V A V Y Q D V Y A V D G P T S L Y H Q A N K G V R V A Y W I G F D T T P F M F K N L A G A Y P S Y S T N W A D E T V L T A R N I G L C S S D V M E R S R R G M S I L R K K Y L K P S N N V L F S V G S T I Y H E K R D L L R S W H L P S V F H L R G K Q N Y T C R C E T I V S C D G Y V V K R I A I S P G L Y G K P S G Y A A T M H R E G F L C C K V T D T L N G E R V S F P V C T Y V P A T L C D Q M T G I L A T D V S A D D A Q K L L V G L N Q R I V V N G R T Q R N T N T M K N Y L L P V V A Q A F A R W A K E Y K E D Q E D E R P L G L R D R Q L V M G C C W A F R R H K I T S I Y K R P D T Q T I I K V N S D F H S F V L P R I G S N T L E I G L R T R I R K M L E E H K E P S P L I T A E D I Q E A K C A A D E A K E V R E A E E L R A A L P P L A A D F E E P T L E A D V D L M L Q E A G A G S V E T P R G L I K V T S Y A G E D K I G S Y A V L S P Q A V L K S E K L S C I H P L A E Q V I V I T H S G R K G R Y A V E P Y H G K V V V P E G H A I P V Q D F Q A L S E S A T I V Y N E R E F V N R Y L H H I A T H G G A L N T D E E Y Y K T V K P S E H D G E Y L Y D I D R K Q C V K K E L V T G L G L T G E L V D P P F H E F A Y E S L R T R P A A P Y Q V P T I G V Y G V P G S G K S G I I K S A V T K K D L V V S A K K E N C A E I I R D V K K M K G L D V N A R T V D S V L L N G C K H P V E T L Y I D E A F A C H A G T L R A L I A I I R P K K A V L C G D P K Q C G F F N M M C L K V H F N H E I C T Q V F H K S I S R R C T K S V T S V V S T L F Y D K R M R T T N P K E T K I V I D T T G S T K P K Q D D L I L T C F R G W V K Q L Q I D Y K G N E I M T A A A S Q G L T R K G V Y A V R Y K V N E N P L Y A P T S E H V N V L L T R T E D R I V W K T L A G D P W I K I L T A K Y P G N F T A T I E E W Q A E H D A I M R H I L E R P D P T D V F Q N K A N V C W A K A L V P V L K T A G I D M T T E Q W N T V D Y F E T D K A H S A E I V L N Q L C V R F F G L D L D S G L F S A P T V P L S I R N N H W D N S P S P N M Y G L N K E V V R Q L S R R Y P Q L P R A V A T G R V Y D M N T G T L R N Y D P R I N L V P V N R R L P H A L V L H H N E H P Q S D F S S F V S K L K G R T V L V V G E K L S V P G K K V D W L S D Q P E A T F R A R L D L G I P G D V P K Y D I V F I N V R T P Y K Y H H Y Q Q C E D H A I K L S M L T K K A C L H L N P G G T C V S I G Y G Y A D R A S E S I I G A I A R Q F K F S R V C K P K S S H E E T E V L F V F I G Y D R K A R T H N P Y K L S S T L T N I Y T G S R L H E A G C A P S Y H V V R G D I A T A T E G V I I N A A N S K G Q P G G G V C G A L Y K K F P E S F D L Q P I E V G K A R L V K G A A K H I I H A V G P N F N K V S E V E G D K Q L A E A Y E S I A K I V N D N N Y K S V A I P L L S T G I F S G N K D R L T Q S L N H L L T A L D T T D A D V A I Y C R D K K W E M T L K E A V A R R E A V E E I C I S D D S S V T E P D A E L V R V H P K S S L A G R K G Y S T S D G K T F S Y L E G T K F H Q A A K D I A E I N A M W P V A T E A N E Q V C M Y I L G E S M S S I R S K C P V E E S E A S T P P S T L P C L C I H A M T P E R V Q R L K A S R P E Q I T V C S S F P L P K Y R I T G V Q K I Q C S Q P I L F S P K V P A Y I H P R K Y L V E T P P V E E T P E S P A E N Q S T E G T P E Q P A L V N V D A T R T R M P E P I I I E E E E E D S I S L L S D G P T H Q V L Q V E A D I H G S P S V S S S S W S I P H A S D F D V D S L S I L D T L D G A S V T S G A V S A E T N S Y F A R S M E F R A R P V P A P R T V F R N P P H P A P R T R T P P L A H S R A S S R T S L V S T P P G V N R V I T R E E L E A L T P S R A P S R S A S R T S L V S N P P G V N R V I T R E E F E A F V A Q Q Q X R F D A G A Y I F S S D T G Q G H L Q Q K S V R Q T V L S E V V L E R T E L E I S Y A P R L D Q E K E E L L R K K L Q L N P T P A N R S R Y Q S R R V E N M K A I T A R R I L Q G L G H Y L K A E G K V E C Y R T L H P V P L Y S S S V N R A F S S P K V A V E A C N A M L K E N F P T V A S Y C I I P E Y D A Y L D M V D G A S C C L D T A S F C P A K L R S F P K K H S Y L E P T I R S A V P S A I Q N T L Q N V L A A A T K R N C N V T Q M R E L P V L D S A A F N V E C F K K Y A C N N E Y W E T F K E N P I R L T E E N V V N Y I T K L K G P K A A A L F A K T H N L N M L Q D I P M D R F V M D L K R D V K V T P G T K H T E E R P K V Q V I Q A A D P L A T A D L C G I H R E L V R R L N A V L L P N I H T L F D M S A E D F D A I I A E H F Q P G D C V L E T D I A S F D K S E D D A M A L T A L M I L E D L G V D A E L L T L I E A A F G E I S S I H L P T K T K F K F G A M M K S G M F L T L F V N T V I N I V I A S R V L R E R L T G S P C A A F I G D D N I V K G V K S D K L M A D R C A T W L N M E V K I I D A V V G E K A P Y F C G G F I L C D S V T G T A C R V A D P L K R L F K L G K P L A V D D E H D D D R R R A L H E E S T R W N R V G I L P E L C K A V E S R Y E T V G T S I I V M A M T T L A S S V K S F S Y L R G A P I T L Y G
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P03317}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250|UniProtKB:P03317}; Note=For nsP4 adenylyltransferase activity; Mn(2+) supports catalysis at 60% of the levels observed with Mg(2+). {ECO:0000250|UniProtKB:P03317}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:P03317}; Note=For nsP4 RNA-directed RNA polymerase activity. {ECO:0000250|UniProtKB:P03317}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:26041283}; Note=For nsP1 guanylylation. {ECO:0000269|PubMed:26041283}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 RNA triphosphatase activity. {ECO:0000250|UniProtKB:Q8JUX6}; COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=For nsP2 NTPase activity. {ECO:0000250|UniProtKB:Q8JUX6};
Active site	ACT_SITE 1012 1012 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.; ACT_SITE 1081 1081 For cysteine protease nsP2 activity. {ECO:0000255|PROSITE-ProRule:PRU00853}.
Pfam	PF01661 PF01707 PF00978 PF01443 PF01660
InterPro	IPR027351 IPR002588 IPR002620 IPR002589 IPR027417 IPR007094 IPR001788