Uniprot ID	P41001
Uniprot Name	TOP2_PLAFK
Taxonomy ID	5839
Sequence	M A K N K T I E E R Y Q K K S Q I E H I L L R P D T Y I G S V E M H T Q L L W V W N K E K N R M V Q K N I T Y V P G L Y K I F D E I I V N A A D V K A R E K E K S E N P M T C I K I E I N K E N K R I S V Y N D G E G I P V D I H K E M N I Y V P H M I F G E L L T S D N Y D D A E D R I T G G R N G F G A K L T N I F S K E F I V Q C G D S S R K K E F K M T W S D N M S K F S E P H I K N Y N G K D Y V K V T F K P D L N K F G M T E M D D D I E S L L F K R V Y D L A G T C S V R V Y L N G Q R L A V K D F K S Y V D L Y L K D N S N D N K N N K G Q N D N N N N N N N N N D E N A N Q N N D N L D V S L S N E P A D G T P T K N N N N N N N N N D E D E I V K I H E K Q H R W E I V V S K S D G S Q F Q Q V S F V N S I C T T K G G S H V N Y I V E Q L L S S L S K K A N A K N K G G M E I K S G H I R N H L W V F V N C L I V N P T F D S Q T K E T L T T K P V K F G S K C I L S D K T I N N V L K S P I L S N I L L W A Q A K A Q V E L K K K M K A G S S K A R E R I I G I P K L E D A N D A G S K Y S Q E C T L I L T E G D S A K T S C L A G L S I V G R D K Y G V F P L K G K L L N V R D A S F K Q L M D N K E I Q N I F R I M G L D I T D K N K D D I K G L R Y G S L M I M T D Q D Y D G S H I K G L L I N M I H K F W P S L L K H K G F L S E F V T P I V K V Q K G S Q E Y S F F T I A E Y E Q W K E N T N L L G W K I K Y Y K G L G T S T D R E F K Q Y F S D I K N H K I M F L W T G D R D G D S I D M A F S K K R I E D R K L W L Q N F I L G S Y V D H K E K D L S Y Y D F V N K E L I Y Y S R Y D T E R S I P N I M D G W K P G Q R K V L Y G C F K R N L R N E C K V A Q L V G Y I A E H S A Y H H H G E S S L Q Q T I I N M A Q T F V G S N N I N F L E P C G Q F G S R K E G G K D A S A A R Y I F T K L A S S T R S I F N E Y D D P I L K Y L N E E G Q K I E P Q Y Y I P V I P T I L V N G C E G I G T G Y S S F I P N Y N Y K D I I D N I K R Y I N K E P L I P M V P W Y K D F K G R I E S N G K T G Y E T I G I I N K I D N D T L E I T E L P I K K W T Q D Y K E F L E E L L T D E K H Q L I L D Y I D N S S H E D I C F T I K M D P A K L Q K A E E E G L E K V F K L K S T L T T T N M T L F D P N L K L Q R Y S T E L D I L K E F C Y Q R L K A Y E N R K S Y L I S K L E K E K R I I S N K T K F I L A I V N N E L I V N K K K K K V L V E E L Y R K G Y D P Y K D I N K I K K E E I F E Q E L L D A A D N P E D N E E I I A G I T V K D Y D Y L L S M P I F S L T L E K V E D L L T Q L K E K E R E L E I L R N I T V E T M W L K D I E K V E E A I E F Q R N V E L S N R E E S N K F K V A R K Q G P S S M K K K K K K K K L S S D E E S E G G D T S D S S E F L V N T L N I K K N T N K K T T T S S N N V N N S K K R L R K A D D L N S N E L D N T L S V S K T F D D N N N L T D N T P L I N R L N D E N N E F S S N N V D N K S T N K N S R K K K P K I A D S T N D N N S E L N S S I Q I N D N V N D D I N I T I S P N K T I N V N E F S S I K N K L L E L G I
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 830 830 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250|UniProtKB:P06786}.
Pfam	PF00204 PF00521 PF02518 PF01751 PF16898
InterPro	IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013757 IPR013759 IPR013506 IPR018522 IPR031660 IPR006171 IPR034157