Uniprot ID	P41516
Uniprot Name	TOP2A_RAT
Taxonomy ID	10116
Sequence	M E L S P L Q P V N E N M L L N K K K N E D G K K R L S V E R I Y Q K K T Q L E H I L L R P D T Y I G S V E L V T Q Q M W V Y D E D V G I N Y R E V T F V P G L Y K I F D E I L V N A A D N K Q R D P K M S C I R V T M M R N N L I S I W N N G K G I P V V E H K V E K M Y V P A L I F G Q L L T S S N Y D D D E K K V T G G R N G Y G A K L C N I F S T K F T V E T A S R E Y K K M F K Q T W M D N M G R A G D M E L K P F S G E D Y T C I T F Q P D L S K F K M Q S L D K D I V A L M V R R A Y D I A G S T K D V K V F L N G N R L P V K G F R S Y V D M Y L K D K V D E T G N A L K V V H E Q V N P R W E V C L T M S E K G F Q Q I S F V N S I A T S K G G R H V D Y V A D Q I V S K L V D V V K K K N K G G V A V K A D Q V K N H M W I F G N A V I E N P T F D S Q T K E N M T L Q A K S F G S T C Q L S E K F I K A A I G C G I V E S I L N W V K F K A Q I Q L N K K C S A V K H N R I K G I P K L D D A N D A G S R N S A E C T L I L T E G D S A K T L A V S G L G V V G R D K Y G V F P L R G K I L N V R E A S H K Q I M E N A E I N N I I K I V G L Q Y K K N Y E D E D S L K T L R Y G K I M I M T D Q D Q D G S H I K G L L I N F I H H N W P S L L R H R F L E E F I T P I V K V S K N K Q E I A F Y S L P E F E E W K S T N P N H K K W K V K Y Y K G L G T S T S K E A K E Y F A N M K R H R I Q F K Y S G P E D D A A I S L A F S K K Q V D D R K E W L T N F M E D R R Q R K L L G L P E D Y L Y G Q T T M Y L T Y N D F I N K E L I L F S N S D N E R S I P S M V D G L K P G Q R K V L F T C F K R N D K R E V K V A Q L A G S V A E M S S Y H H G E M S L M M T I I N L A Q N F V G S N N L N L L Q P I G Q F G T R L H G G K D S A S P R Y I F T M L S P L A R L L F P S K D D H T L R F L Y D D N Q R V E P E W Y I P I I P M V L I N G A E G I G T G W S C K I P N F D V R E V V N N I R R L L D G E E P L P M L P S Y K N Y K G T I E E L A S N Q Y V I N G E V A I L N S T T I E I T E L P I R T W T Q T Y K E Q V L E P M L N G T E K T P P L I T D Y R E Y H T D T T V K F V I K M T E E K L A E A E R V G L H K V F K L Q T S L T C N S M V L F D H V G C L K K Y D T V L D I L R D F F E L R L K Y Y G L R K E W L L G M L G A E S S K L N N Q A R F I L E K I D G K I V I E N K P K K E L I K V L I Q R G Y D S D P V K A W K E A Q Q K V P E E E E N E E N E E S E S E S T S P A A E S G P T F N Y L L D M P L W Y L T K E K K D E L C K Q R D E K E Q E L N T L K K K T P S D L W K E D L A A F V E E L E V V E A K E K Q D E Q V G L P G K G V K A K G K K A Q I S E V L P S P V G K R V I P Q V T M E M R A E A E K K I R R K I K S E N V E G T P A E D G A E P G L R Q R L E K R Q K R E P G T R A K K Q T T L P F K P I K K A Q K Q N P W S D S E S D M S S N E S N F D V P P R E K E P R I A A T K A K F T A D L D S D D D F S G L D E K D E D E D F F P L D D T P P K T K M P P K N T K K A L K P Q K S S T S V D L E S D G K D S V P A S P G A S A A D V P A E T E P S K P S S K Q T V G V K R T I T K G Q S L T S T A G T K K R A V P K E T K S D S A L N A H V S K K P A P A K A K N S R K R M P S S S D S S D S E F E K A I S K G A T S K K L K G E E R D F H V D L D D T V A P R A K S G R A R K P I K Y L E E S D D D L F
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|PROSITE-ProRule:PRU00995}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|PROSITE-ProRule:PRU00995};
Active site	ACT_SITE 803 803 O-(5'-phospho-DNA)-tyrosine intermediate. {ECO:0000250|UniProtKB:P06786}.
Pfam	PF00204 PF00521 PF08070 PF02518 PF01751 PF16898
InterPro	IPR012542 IPR003594 IPR036890 IPR020568 IPR014721 IPR001241 IPR013760 IPR002205 IPR013758 IPR013759 IPR013506 IPR018522 IPR031660 IPR006171 IPR034157