Uniprot ID	P57927
Uniprot Name	TKT1_PASMU
Taxonomy ID	272843
Sequence	M A T R R E L A N A I R F L S M D A V Q K A K S G H P G A P M G M A D I A E V L W R D F L K H N P S N P H W A D R D R F I L S N G H G S M L I Y S L L H L S G Y D L S I E D L K Q F R Q L H S K T P G H P E Y G Y A P G V E T T T G P L G Q G I T N A V G F A I A E K T L A H Q F N R P G H E I V D H H T Y V F L G D G C L M E G I S H E A C S L A G T L G L G K L I A F Y D D N N I S I D G H V D G W F T D D T Q K R F E A Y G W H V I P A V D G H N P E Q I L E A V K Q A Q A E T T K P T L I I C K T I I G Y G S P N K A N S H D C H G A P L G D D E I A A A R E F L K W E H A P F E I P A E I Y A Q W D A K E K G Q V A E K A W E E K L A A Y A K A Y P E L A A E F T R R V N A E L P A N W A A E S Q A F I E H L Q A N P A N I A S R K A S Q N A I E A Y A K L L P E F L G G S A D L A S S N L T L W S G S K P I R A V E N A D G N Y I N Y G V R E F G M S A I M N G I A L H G G F I P Y G A T F L M F M E Y A H N A V R M A A L M K Q R S L F V Y T H D S I G L G E D G P T H Q P V E Q T S A L R L I P N L E T W R P C D Q V E S A V A W K A A V E R K E G P S A L I F T R Q N L A Q M D R T A E Q L A N V A R G G Y V L R H C C E N Q N C P D L I L I A T G S E V E L A M K A A D V L D A E G V K V R V V S M P S T N V F D K Q D A A Y R E S V L P S H I T K R V A I E A G I A D F W Y K Y V G F E G R V V G M N S F G E S A P A D Q L F K L F G F T V E N I V E K A K A I L
Cofactor	COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000250}; Note=Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+). {ECO:0000250}; COFACTOR: Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO:0000250};
Active site	ACT_SITE 413 413 Proton donor. {ECO:0000250}.
Pfam	PF02779 PF02780 PF00456
InterPro	IPR029061 IPR009014 IPR005475 IPR005478 IPR020826 IPR033248 IPR033247 IPR005474